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首页> 外文期刊>Clinical & developmental immunology. >Tumor Protective Activity of CD4+ but Not of CD8+ T Cells in DNA-Vaccinated Mice Challenged with bcr-abl-Transformed Cells
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Tumor Protective Activity of CD4+ but Not of CD8+ T Cells in DNA-Vaccinated Mice Challenged with bcr-abl-Transformed Cells

机译：在受bcr-abl转化的细胞攻击的DNA疫苗接种的小鼠中，CD4 +而不是CD8 + T细胞具有肿瘤保护活性。

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In the recent past, it has repeatedly been reported that CD4 cells play an important role in the immunology of chronic myeloid leukaemia. It was therefore of interest to test their activity in an animal model using bcr-abl-transformed cells. BALB/c mice were four times immunized with a DNA vaccine carrying the bcr-abl fusion gene. Two weeks after the last vaccine dose, the animals were challenged with syngeneic bcr-abl-transformed 12B1 cells which form solid tumors after subcutaneous administration. At the time of challenge, animals were treated with antibodies against the CD8+ T cells or CD4+ T cells. The efficacy of the depletion was monitored and found highly effective. All nonimmunized animals developed tumors. All animals untreated with the antibodies as well as those in which CD8+ T cells had been depleted, were fully protected against the challenge. On the other hand, almost all mice treated with anti-CD4+ antibody developed tumors. These results strongly suggested that the CD4+ T cells acted as effectors in the present system.
机译：在最近的过去，已经反复地报道CD4细胞在慢性粒细胞白血病的免疫学中起重要作用。因此，感兴趣的是使用bcr-abl转化的细胞在动物模型中测试其活性。用携带bcr-abl融合基因的DNA疫苗对BALB / c小鼠免疫四次。在最后一次疫苗注射后两周，用经同基因的bcr-abl转化的12B1细胞攻击动物，这些细胞在皮下给药后形成实体瘤。攻击时，用针对CD8 + T细胞或CD4 + T细胞的抗体治疗动物。监测了消耗的功效并发现其非常有效。所有未免疫的动物都患有肿瘤。所有未经抗体处理的动物以及已耗尽CD8 + T细胞的动物均受到充分保护，免受攻击。另一方面，几乎所有用抗CD4 +抗体治疗的小鼠都出现了肿瘤。这些结果强烈提示CD4 + T细胞在本系统中充当效应子。

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