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首页> 外文期刊>Clinical & developmental immunology. >Immune Response to Mycobacterial Infection: Lessons from Flow Cytometry
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Immune Response to Mycobacterial Infection: Lessons from Flow Cytometry

机译：对分枝杆菌感染的免疫反应：流式细胞术的经验教训

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摘要

Detecting and treating active and latent tuberculosis are pivotal elements for effective infection control; yet, due to their significant inherent limitations, the diagnostic means for these two stages of tuberculosis (TB) to date remain suboptimal. This paper reviews the current diagnostic tools for mycobacterial infection and focuses on the application of flow cytometry as a promising method for rapid and reliable diagnosis of mycobacterial infection as well as discrimination between active and latent TB: it summarizes diagnostic biomarkers distinguishing the two states of infection and also features of the distinct immune response against Mycobacterium tuberculosis ( Mtb ) at certain stages of infection as revealed by flow cytometry to date.
机译：检测和治疗活动性和潜伏性结核病是有效控制感染的关键要素。然而，由于其明显的固有局限性，迄今为止，这两个阶段的结核病（TB）的诊断方法仍然欠佳。本文回顾了当前的分枝杆菌感染诊断工具，重点介绍了流式细胞术作为一种快速，可靠诊断分枝杆菌感染以及区分活动性结核病和潜伏性结核病的有前途的方法：总结了区分两种感染状态的诊断性生物标志物到目前为止，还具有在感染的某些阶段针对结核分枝杆菌（Mtb）的独特免疫反应的特征。

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