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首页> 外文期刊>Clinical & developmental immunology. >HLA-B ?57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India
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HLA-B ?57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India

机译：HLA-B ？ 57和性别影响印度南部艾滋病毒感染者中结核的发生

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Background . Substantial evidence exists for HLA and other host genetic factors being determinants of susceptibility or resistance to infectious diseases. However, very little information is available on the role of host genetic factors in HIV-TB coinfection. Hence, a longitudinal study was undertaken to investigate HLA associations in a cohort of HIV seropositive individuals with and without TB in Bangalore, South India. Methods . A cohort of 238?HIV seropositive subjects were typed for HLA-A, B, and DR by PCR-SSP and followed up for 5?years or till manifestation of Tuberculosis. HLA data of 682?HIV Negative healthy renal donors was used as control. Results . The ratio of males and females in HIV cohort was comparable (50.4% and 49.6%). But the incidence of TB was markedly lower in females (12.6%,) than males (25.6%). Further, HLA-B*57 frequency in HIV cohort was significantly higher among females without TB (21.6%, 19/88) than males (1.7%, 1/59); P = 0.0046; OR = 38. CD4 counts also were higher among females in this cohort. Conclusion . This study suggests that HIV positive women with HLA-B*57 have less occurrence of TB as compared to males.
机译：背景 。存在大量证据表明HLA和其他宿主遗传因素是感染性疾病易感性或耐药性的决定因素。但是，关于宿主遗传因素在HIV-TB合并感染中的作用的信息很少。因此，在印度南部的班加罗尔进行了一项纵向研究，调查了有和没有结核病的HIV血清阳性个体队列中的HLA关联。方法 。通过PCR-SSP对238名HIV血清反应阳性的受试者进行HLA-A，B和DR分型，并随访5年或直至出现结核病。以682例HIV阴性健康肾脏供者的HLA数据为对照。结果。艾滋病毒队列中的男女比例相当（50.4％和49.6％）。但是，女性（12.6％）的结核病发病率明显低于男性（25.6％）。此外，在没有结核病的女性中，HIV队列中HLA-B * 57的频率显着高于男性（1.7％，1/59）（21.6％，19/88）。 P = 0.0046; OR =38。该队列中女性的CD4计数也较高。结论。这项研究表明，与男性相比，患有HLA-B * 57的HIV阳性女性的结核病发病率更低。

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