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首页> 外文期刊>Clinical & developmental immunology. >Comparative Approach to Define Increased Regulatory T Cells in Different Cancer Subtypes by Combined Assessment of CD127 and FOXP3
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Comparative Approach to Define Increased Regulatory T Cells in Different Cancer Subtypes by Combined Assessment of CD127 and FOXP3

机译：通过联合评估CD127和FOXP3定义不同癌症亚型中增加的调节性T细胞的比较方法

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In recent years an increase of functional CD4~(+)CD25~(+)regulatory T cells (T_(reg)cells) has been established for patients with solid tumors, acute leukemias, and lymphomas. We have reported an expanded pool of CD4~(+)CD25~(high)T_(reg)cells in patients with chronic lymphatic leukemia (CLL), multiple myeloma (MM) as well as its premalignant precursor monoclonal gammopathy of undetermined significance (MGUS). In healthy individuals, low-level expression of CD127 on T cells in addition to the expression of FOXP3 has been associated with T_(reg)cells. Here, we demonstrate that the expanded FOXP3~(+)T-cell population in patients with colorectal cancer, CLL, MGUS, MM, follicular lymphoma, and Hodgkin's disease are exclusively CD127~(low)T_(reg)cells and were strongly suppressive. A significant portion of CD127~(low)FOXP3~(+)T_(reg)cells expressed only low levels of CD25 suggesting that the previously reported expansion of CD25~(+)T_(reg)cells underestimates the true expansion. The assessment of CCR7 and CD45RA expression on the expanded CD4~(+)CD127~(low)FOXP3~(+)T_(reg)cells revealed an increase of both na?ve as well as central and effector memory T_(reg)cells in peripheral blood. Our data strongly support superiority of combined CD127 and FOXP3 analysis in comparison to CD25 and FOXP3 assessment for further quantification of T_(reg)cells in malignant diseases.
机译：近年来，已经为患有实体瘤，急性白血病和淋巴瘤的患者建立了功能性CD4〜（+）CD25〜（+）调节性T细胞（T_（reg）细胞）的增加。我们已经报道了在慢性淋巴白血病（CLL），多发性骨髓瘤（MM）以及其恶性前体单克隆γ病（未确定意义）的患者中，CD4〜（+）CD25〜（高）T_（reg）细胞池的扩大）。在健康个体中，除了FOXP3的表达外，T细胞上CD127的低水平表达也与T_reg细胞有关。在这里，我们证明在结直肠癌，CLL，MGUS，MM，滤泡性淋巴瘤和霍奇金病患者中，FOXP3〜（+）T细胞数量的增加仅是CD127〜（低）T_（reg）细胞，并且具有强抑制性。 CD127〜（低）FOXP3〜（+）T_（reg）细胞的很大一部分仅表达低水平的CD25，这表明先前报道的CD25〜（+）T_（reg）细胞的扩增低估了真正的扩增。在扩增的CD4〜（+）CD127〜（低）FOXP3〜（+）T_（reg）细胞上评估CCR7和CD45RA的表达揭示了幼稚以及中央和效应记忆T_（reg）细胞的增加在外周血中。与CD25和FOXP3评估相比，我们的数据强烈支持CD127和FOXP3联合分析在恶性疾病中T_（reg）细胞进一步量化方面的优越性。

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