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首页> 外文期刊>Clinical & developmental immunology. >Clinical Characteristics of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in North Indian Population of HIV/AIDS Patients Receiving HAART
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Clinical Characteristics of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in North Indian Population of HIV/AIDS Patients Receiving HAART

机译：在印度北部接受HAART的HIV / AIDS患者中，结核相关的免疫重建炎症综合症的临床特征

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Background & Objective . IRIS is an important complication that occurs during management of HIV-TB coinfection and it poses difficulty in diagnosis. Previous studies have reported variable incidence of IRIS. The present study was undertaken to describe the pattern of TB-associated IRIS using recently proposed consensus case-definitions for TB-IRIS for its use in resource-limited settings. Methods . A prospective analysis of ART-na?ve adults started on HAART from November, 2008 to May, 2010 was done in a tertiary care hospital in north India. A total 224 patients divided into two groups, one with HIV-TB and the other with HIV alone, were followedup for a minimum period of 3 months. The diagnosis of TB was categorised as ‘‘definitive” and ‘‘probable”. Results . Out of a total of 224 patients, 203 completed followup. Paradoxical TB-IRIS occurred in 5 of 123 (4%) HIV-TB patients while 6 of 80 (7.5%) HIV patients developed ART-associated TB. A reduction in plasma viral load was significantly ( P = .016) associated with paradoxical TB-IRIS. No identifiable risk factors were associated with the development of ART-associated TB. Conclusion . The consensus case-definitions are useful tools in the diagnosis of TB-associated IRIS. High index of clinical suspicion is required for an early diagnosis.
机译：背景与目的。 IRIS是在HIV-TB合并感染管理期间发生的重要并发症，并给诊断带来了困难。先前的研究报道了IRIS的可变发病率。进行本研究以描述TB相关的IRIS的模式，使用最近提出的针对TB-IRIS的共识病例定义以在资源有限的环境中使用。方法 。在2008年11月至2010年5月期间，在印度北部的一家三级护理医院对未接受过ART治疗的成年人进行了前瞻性分析。总共224名患者被分为两组，一组患有HIV-TB，另一组仅患有HIV，随访至少3个月。结核病的诊断分为“确定性”和“可能性”。结果。在总共224位患者中，有203位完成了随访。 123例HIV-TB患者中有5例发生悖论性TB-IRIS，而80例HIV患者（7.5％）中有6例发生了ART相关结核。与反常的TB-IRIS相关的血浆病毒载量显着降低（P = .016）。没有可识别的危险因素与ART相关结核的发生有关。结论。共识病例定义是诊断结核病相关IRIS的有用工具。早期诊断需要较高的临床怀疑指数。

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