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首页> 外文期刊>Comparative Medicine >Cortisol and Prolactin Concentrations During Repeated Blood Sample Collection from Freely Moving, Mouse-sized Mammals (Phodopus spp.)
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Cortisol and Prolactin Concentrations During Repeated Blood Sample Collection from Freely Moving, Mouse-sized Mammals (Phodopus spp.)

机译：从活动自如的小鼠大小的哺乳动物（Phodopus spp。）重复采集血液样本中的皮质醇和催乳素浓度。

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BackgroundandPurpose:Validationofamethodforobtainingbloodsamplesthatdoesnotchangecortisolorprolactinconcentrationsyetallowsserialbloodsamplestobecollectedfromanimalsunderanesthesia,withoutpriorhandling,fromfreelyinteractingsocialgroupsofsmallmammals.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Resultsfromfiveexperimentsarereported.Maledwarfhamsters(Phodopusspp.)werehousedinmodifiedhomecagesundercontinuousflowofcompressedairthatcouldbeswitchedtoisofluraneinOsubxmlns="http://pub2web.metastore.ingenta.coms/"2/subvehiclewithoutapproachingthecages.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Dwarfhamstersrespondtomanualrestraintwithbehavioraldistressandincreaseintheconcentrationofthedominantglucocorticoid,cortisol,anddecreaseinprolactinconcentration.Botheffectsareevidentwithinoneminute.Incontrast,whenthisnewmethodwasused,neithercortisolnorprolactinchangedinresponsetorepeatedsamplecollection(upto8successivesamplesat2hourintervals),prolongedisofluraneexposure,orsubstantialbloodvolumereduction(30%).Prolactinconcentrationwassuppressedandcortisolconcentrationwasincreasedinresponsetostimulifromotherhamsterstestedwithoutanesthesia.Suppressionofprolactinconcentrationwasgradedinresponsetothedegreeofstressandequaledthepharmacologicreductioncausedbybromocryptinemesylate(50#59157;gofCB154x3days).brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:Thetechniqueissuperiortoalternativesforstudiesofbehavioralendocrinologyoffreelyinteractingsmallmammals.
机译：BackgroundandPurpose：Validationofamethodforobtainingbloodsamplesthatdoesnotchangecortisolorprolactinconcentrationsyetallowsserialbloodsamplestobecollectedfromanimalsunderanesthesia，withoutpriorhandling，fromfreelyinteractingsocialgroupsofsmallmammals 方法：Resultsfromfiveexperimentsarereported.Maledwarfhamsters（Phodopusspp）werehousedinmodifiedhomecagesundercontinuousflowofcompressedairthatcouldbeswitchedtoisofluraneinO 2 车辆，没有接近笼子。相反，当使用这种新方法时，两种效果均不会明显发生，皮质醇或催乳激素的变化都不会改变响应集的采样率（每2小时间隔最多采样8次），isoflu延长。raneexposure，orsubstantialbloodvolumereduction（30％）Prolactinconcentrationwassuppressedandcortisolconcentrationwasincreasedinresponsetostimulifromotherhamsterstestedwithoutanesthesia.Suppressionofprolactinconcentrationwasgradedinresponsetothedegreeofstressandequaledthepharmacologicreductioncausedbybromocryptinemesylate（50＃59157; gofCB154x3days） 结论：Thetechniqueissuperiortoalternativesforstudiesofbehavioralendocrinologyoffreelyinteractingsmallmammals。

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