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首页> 外文期刊>Comparative Medicine >Selection of the Most Efficacious of Twenty-Two Inactivated Sendai Virus Nasal Vaccines by Determination of the Protection Index in Mice
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Selection of the Most Efficacious of Twenty-Two Inactivated Sendai Virus Nasal Vaccines by Determination of the Protection Index in Mice

机译：通过确定小鼠保护指数来选择二十二种灭活的仙台病毒鼻疫苗中最有效的

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BackgroundandPurpose:Sendaivirusnasalvaccinesinactivatedwithvariouschemicalsinducecompleteprotectionagainstcontact-challengeexposurewiththeNagoyastrain.Thestudyreportedherewastoreevaluatetheefficacyoftheinactivantsbydeterminingtheprotectiveindex(PI)inmice,usingthemorevirulentMNstrain.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Miceweregiveneachof22inactivatedvaccinesintranasallythreetimes.Afterchallengeexposurewith10supxmlns="http://pub2web.metastore.ingenta.coms/"-2/supto10supxmlns="http://pub2web.metastore.ingenta.coms/"6/supMIDsubxmlns="http://pub2web.metastore.ingenta.coms/"50/subofvirus,infectionofcellsoftherespiratorytractwasdeterminedbyimmunofluorescence.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:TwelvevaccinesinducedPI#8805;2.0inthenasalmucosaandwereclassifiedasgroup1.ThefirsthalfoftheprecedingvaccinesthatinducedPI#8805;3.2inthelarynxwereclassifiedsubgroupa,andtherestwereclassifiedsubgroupb.Oftheother10vaccines,6thatinducedPI#8804;2.0inthelarynxand4thatinducedintermediatePIinthenasalmucosaandlarynxwererankedasgroups3and2,respectively;PIofthetracheadecreasedbynumericorderofgroups.Serumhemagglutinationinhibitiontiterinducedbyintranasalvaccinationwaslowingeneral.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusion:OnthebasisofPIvalues,6ofthe22nasalvaccinesprovidedthestrongestdefenseintherespiratorytract.
机译：BackgroundandPurpose：Sendaivirusnasalvaccinesinactivatedwithvariouschemicalsinducecompleteprotectionagainstcontact-challengeexposurewiththeNagoyastrain.Thestudyreportedherewastoreevaluatetheefficacyoftheinactivantsbydeterminingtheprotectiveindex（PI）inmice，usingthemorevirulentMNstrain 方法：Miceweregiveneachof22inactivatedvaccinesintranasallythreetimes.Afterchallengeexposurewith10 -2to106MID 50 病毒的感染，通过免疫荧光确定了细胞在此处的呼吸道感染。 结果：将十二个在鼻粘膜上诱导的PI＃8805; 2.0疫苗分类为第1组。在上半部诱导PI＃8805; 3.2在喉中的疫苗分类为a组，其余的又分类为b组。另外10个疫苗，第6组nducedPI＃8804; 2.0inthelarynxand4thatinducedintermediatePIinthenasalmucosaandlarynxwererankedasgroups3and2，分别; PIofthetracheadecreasedbynumericorderofgroups.Serumhemagglutinationinhibitiontiterinducedbyintranasalvaccinationwaslowingeneral 结论：OnthebasisofPIvalues，6ofthe22nasalvaccinesprovidedthestrongestdefenseintherespiratorytract。

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