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首页> 外文期刊>Biology Open >Heparan sulfate negatively regulates intestinal stem cell proliferation in Drosophila adult midgut
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Heparan sulfate negatively regulates intestinal stem cell proliferation in Drosophila adult midgut

机译：硫酸乙酰肝素负调节果蝇成年中肠肠道干细胞增殖。

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Tissue homeostasis is maintained by differentiated progeny of residential stem cells. Both extrinsic signals and intrinsic factors play critical roles in the proliferation and differentiation of adult intestinal stem cells (ISCs). However, how extrinsic signals are transduced into ISCs still remains unclear. Here, we find that heparan sulfate (HS), a class of glycosaminoglycan (GAG) chains, negatively regulates progenitor proliferation and differentiation to maintain midgut homeostasis under physiological conditions. Interestingly, HS depletion in progenitors results in inactivation of Decapentaplegic (Dpp) signaling. Dpp signal inactivation in progenitors resemblesHS-deficientintestines. Ectopic Dpp signaling completely rescued the defects caused by HS depletion. Taken together, these data demonstrate that HS is required for Dpp signaling to maintain midgut homeostasis. Our results provide insight into the regulatory mechanisms of how extrinsic signals are transduced into stem cells to regulate their proliferation and differentiation.
机译：组织稳态由居住干细胞的分化后代维持。外在信号和内在因素在成年肠道干细胞（ISC）的增殖和分化中都起着关键作用。然而，如何将外在信号转导至ISC尚不清楚。在这里，我们发现硫酸乙酰肝素（HS）是一类糖胺聚糖（GAG）链，在生理条件下负调节祖细胞的增殖和分化，以维持中肠稳态。有趣的是，祖细胞中的HS耗竭导致十足瘫痪（Dpp）信号传导失活。祖细胞中的Dpp信号失活类似于HS缺陷型肠道。异位Dpp信号完全消除了HS耗竭引起的缺陷。综上所述，这些数据表明Dpp信号传导需要维持HS来维持中肠稳态。我们的结果提供了对外源信号如何转导至干细胞以调节其增殖和分化的调控机制的见解。

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