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首页> 外文期刊>Biology Open >Bridging the gap between postembryonic cell lineages and identified embryonic neuroblasts in the ventral nerve cord of Drosophila melanogaster
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Bridging the gap between postembryonic cell lineages and identified embryonic neuroblasts in the ventral nerve cord of Drosophila melanogaster

机译：弥合果蝇腹侧神经线中的胚胎后细胞谱系与已鉴定的胚胎神经母细胞之间的间隙

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The clarification of complete cell lineages, which are produced by specific stem cells, is fundamental for understanding mechanisms, controlling the generation of cell diversity and patterning in an emerging tissue. In the developing Central Nervous System (CNS) of Drosophila , neural stem cells (neuroblasts) exhibit two periods of proliferation: During embryogenesis they produce primary lineages, which form the larval CNS. After a phase of mitotic quiescence, a subpopulation of them resumes proliferation in the larva to give rise to secondary lineages that build up the CNS of the adult fly. Within the ventral nerve cord (VNC) detailed descriptions exist for both primary and secondary lineages. However, while primary lineages have been linked to identified neuroblasts, the assignment of secondary lineages has so far been hampered by technical limitations. Therefore, primary and secondary neural lineages co-existed as isolated model systems. Here we provide the missing link between the two systems for all lineages in the thoracic and abdominal neuromeres. Using the Flybow technique, embryonic neuroblasts were identified by their characteristic and unique lineages in the living embryo and their further development was traced into the late larval stage. This comprehensive analysis provides the first complete view of which embryonic neuroblasts are postembryonically reactivated along the anterior/posterior-axis of the VNC, and reveals the relationship between projection patterns of primary and secondary sublineages.
机译：由特定干细胞产生的完整细胞谱系的澄清，对于理解机制，控制细胞多样性的产生以及在新兴组织中的模式形成至关重要。在发育中的果蝇中枢神经系统（CNS）中，神经干细胞（成神经细胞）表现出两个增殖时期：胚胎发生过程中，它们会产生初级谱系，形成幼虫CNS。在有丝分裂静止期之后，它们的一个亚群在幼虫中恢复增殖，从而产生次级谱系，从而形成了成年果蝇的中枢神经系统。在腹神经索（VNC）中，存在针对主要谱系和次要谱系的详细描述。但是，尽管主要谱系已与已鉴定的成神经细胞相关联，但迄今为止，次要谱系的分配受到技术限制的阻碍。因此，初级和次级神经谱系共存为孤立的模型系统。在这里，我们为胸和腹神经绒毛的所有谱系提供了两个系统之间缺少的联系。使用Flybow技术，通过在活胚胎中的特征和独特的血统来鉴定胚胎成神经细胞，并将其进一步发育追溯到幼虫后期。这项全面的分析提供了关于哪个胚神经母细胞沿VNC的前/后轴进行胚胎后活化的第一个完整视图，并揭示了主要和次要亚系的投影模式之间的关系。

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