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首页> 外文期刊>Biology Open >The impact of FOXO on dopamine and octopamine metabolism in?Drosophila?under normal and heat stress conditions
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The impact of FOXO on dopamine and octopamine metabolism in?Drosophila?under normal and heat stress conditions

机译：在正常和热应激条件下，FOXO对果蝇中多巴胺和章鱼胺代谢的影响

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The forkhead boxO transcription factor (FOXO) is a component of the insulin signalling pathway and plays a role in responding to adverse conditions, such as oxidative stress and starvation. In stressful conditions, FOXO moves from the cytosol to the nucleus where it activates gene expression programmes. Here, we show that FOXO in?Drosophila melanogaster?responds to heat stress as it does to other stressors. The catecholamine signalling pathway is another component of the stress response. In?Drosophila, dopamine and octopamine levels rise steeply under heat, nutrition and mechanical stresses, which are followed by a decrease in the activity of synthesis enzymes. We demonstrate that the nearly twofold decline of FOXO expression in?foxoBG01018?mutants results in dramatic changes in the metabolism of dopamine and octopamine and the overall response to stress. The absence of FOXO increases tyrosine decarboxylase activity, the first enzyme in octopamine synthesis, and decreases the enzymatic activity of enzymes in dopamine synthesis, alkaline phosphatase and tyrosine hydroxylase, in young?Drosophila?females. We identified the juvenile hormone as a mediator of FOXO regulation of catecholamine metabolism. Our findings suggest that FOXO is a possible trigger for endocrinological stress reactions.
机译：叉头盒O转录因子（FOXO）是胰岛素信号传导途径的组成部分，并在应对不利条件（例如氧化应激和饥饿）中起作用。在压力条件下，FOXO从细胞质移到细胞核，从而激活基因表达程序。在这里，我们表明果蝇中的FOXO对热应激的反应与对其他应激源的反应一样。儿茶酚胺信号传导途径是应激反应的另一部分。在果蝇中，在热，营养和机械应力下，多巴胺和章鱼胺的含量急剧上升，随后合成酶的活性下降。我们证明，foxoBG01018突变体中FOXO表达的下降将近两倍导致多巴胺和章鱼胺的代谢以及对压力的整体反应的急剧变化。在年轻的果蝇中，FOXO的缺乏增加了酪氨酸脱羧酶的活性，这是章鱼胺合成中的第一种酶，并且降低了多巴胺合成中的酶的酶活性，碱性磷酸酶和酪氨酸羟化酶。我们确定了少年激素是儿茶酚胺代谢的FOXO调节介质。我们的发现表明FOXO可能是内分泌应激反应的触发因素。

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