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首页> 外文期刊>Biology Open >Amyloids assemble as part of recognizable structures during oogenesis in Xenopus
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Amyloids assemble as part of recognizable structures during oogenesis in Xenopus

机译：淀粉样蛋白在爪蟾成卵过程中组装为可识别结构的一部分。

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A hallmark of Alzheimer's, Huntington's and similar diseases is the assembly of proteins into amyloids rather than folding into their native state. There is an increasing appreciation that amyloids, under specific conditions, may be non-pathogenic. Here we show that amyloids form as a normal part of?Xenopus?oocyte development. Amyloids are detectable in the cytosol and the nucleus using an amyloid binding dye and antibodies that recognize amyloid structure. In the cytosol, yolk platelets are amyloid reactive, as are a number of yet to be characterized particles. In the nucleus, we find particles associated with transcription by RNA polymerase I, II and III and RNA processing contain amyloids. Nuclear amyloids remain intact for hours following isolation; however, RNase treatment rapidly disrupts nuclear amyloids.
机译：阿尔茨海默氏病，亨廷顿氏病和类似疾病的标志是蛋白质组装成淀粉样蛋白，而不是折叠成天然状态。人们越来越认识到，淀粉样蛋白在特定条件下可能是非致病性的。在这里，我们显示淀粉样蛋白是非洲爪蟾卵母细胞发育的正常部分。使用淀粉样蛋白结合染料和识别淀粉样蛋白结构的抗体，可以在细胞质和细胞核中检测淀粉样蛋白。在细胞质中，卵黄血小板与淀粉样蛋白具有反应性，许多尚未鉴定的颗粒也是如此。在细胞核中，我们发现与RNA聚合酶I，II和III转录相关的颗粒，RNA加工过程中含有淀粉样蛋白。分离后几个小时，核淀粉样蛋白仍保持完整。但是，RNase处理会迅速破坏核淀粉样蛋白。

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