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首页> 外文期刊>Biology Open >Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease
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Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease

机译：树sh（Tupaia belangeri chinensis），一种非酒精性脂肪肝疾病的新型非肥胖动物模型

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Non-alcoholic fatty liver disease (NAFLD) is becoming a severe public health problem that is affecting a large proportion of the world population. Generally, NAFLD in patients is usually accompanied by obesity, hyperglycemia, insulin resistance (IR) and type 2 diabetes (T2D), for which numerous animal models have been generated in order to explore the pathogenesis and therapies of NAFLD. On the contrary, quite a number of NAFLD subjects, especially in Asian regions, are non-obese and non-diabetic; however, few animal models are available for the research of non-obese NAFLD. Here, four approaches (here called approach 1 to 4) corresponding to the variable compositions of diets were used to treat tree shrews (Tupaia belangeri chinensis), which have a closer evolutionary relationship to primates than rodents. Analysis of plasma biochemical parameters, hepatic histology, and the expression of hepatic lipid metabolic genes revealed that all four approaches led to hepatic lipid accumulation, liver injury and hypercholesterolemia, but had no effect on body weight and adipose tissue generation, or glycemia. Hepatic gene expression in tree shrews treated by approach 4 might suggest a different or non-canonical pathway leading to hepatic steatosis. In conclusion, the tree shrew displays hepatic steatosis and dyslipidemia, but remains non-obese and non-diabetic under high energy diets, which suggests that the tree shrew may be useful as a novel animal model for the research of human non-obese NAFLD.
机译：非酒精性脂肪肝疾病（NAFLD）正成为严重的公共卫生问题，正在影响世界很大比例的人口。通常，患者中的NAFLD通常伴有肥胖，高血糖，胰岛素抵抗（IR）和2型糖尿病（T2D），为此已经建立了许多动物模型以探讨NAFLD的发病机理和治疗方法。相反，相当多的NAFLD受试者，特别是在亚洲地区，是非肥胖和非糖尿病的。但是，很少有动物模型可用于非肥胖NAFLD的研究。在这里，使用四种与饮食的不同组成相对应的方法（此处称为方法1-4）来处理树木sh（Tupaia belangeri chinensis），它们与灵长类动物的进化关系比啮齿动物更近。对血浆生化参数，肝组织学和肝脂质代谢基因表达的分析表明，所有四种方法均导致肝脂质蓄积，肝损伤和高胆固醇血症，但对体重和脂肪组织生成或血糖没有影响。通过方法4处理的树sh中的肝基因表达可能暗示了导致肝脂肪变性的不同途径或非经典途径。总之，该树sh显示出肝脏脂肪变性和血脂异常，但在高能量饮食下仍保持非肥胖和非糖尿病状态，这表明该树sh可以作为研究人类非肥胖NAFLD的新型动物模型。

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