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首页> 外文期刊>Biology Open >Selector genes display tumor cooperation and inhibition in?Drosophila?epithelium in a developmental context-dependent manner
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Selector genes display tumor cooperation and inhibition in?Drosophila?epithelium in a developmental context-dependent manner

机译：选择基因在果蝇上皮细胞中以发展背景依赖的方式显示肿瘤的协同作用和抑制作用

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During animal development, selector genes determine identities of body segments and those of individual organs. Selector genes are also misexpressed in cancers, although their contributions to tumor progression per se remain poorly understood. Using a model of cooperative tumorigenesis, we show that gain of selector genes results in tumor cooperation, but in only select developmental domains of the wing, haltere and eye-antennal imaginal discs of?Drosophila?larva. Thus, the field selector, Eyeless (Ey), and the segment selector, Ultrabithorax (Ubx), readily cooperate to bring about neoplastic transformation of cells displaying somatic loss of the tumor suppressor, Lgl, but in only those developmental domains that express the homeo-box protein, Homothorax (Hth), and/or the Zinc-finger protein, Teashirt (Tsh). In non-Hth/Tsh-expressing domains of these imaginal discs, however, gain of Ey in?lgl??somatic clones induces neoplastic transformation in the distal wing disc and haltere, but not in the eye imaginal disc. Likewise, gain of?Ubx?in?lgl??somatic clones induces transformation in the eye imaginal disc but not in its endogenous domain, namely, the haltere imaginal disc. Our results reveal that selector genes could behave as tumor drivers or inhibitors depending on the tissue contexts of their gains.
机译：在动物发育过程中，选择基因决定了身体各部分的身份以及各个器官的身份。选择基因在癌症中也被错误表达，尽管它们对肿瘤进展本身的贡献仍知之甚少。使用合作的肿瘤发生模型，我们表明选择基因的获得导致肿瘤的合作，但只在果蝇幼虫的翅膀，三角翼和眼前的假想椎间盘的选定发育区域内发生。因此，场选择器Eyeless（Ey）和段选择器Ultrabithorax（Ubx）可以很容易地协同合作，实现肿瘤抑制因子Lgl体细胞丧失的细胞的肿瘤转化，但仅限于表达同源序列的发育域盒蛋白，高胸腺激素（Hth）和/或锌指蛋白，茶衫（Tsh）。然而，在这些假想椎间盘的非Hth / Tsh表达域中，Ey1α1体细胞克隆中Ey的获得诱导了远侧翼状椎间盘和三角hal的赘生性转化，但在眼睛假想椎间盘中却没有。同样，在“ IgG1”体细胞克隆中“ Ubx”的获得诱导了在眼中的视盘中的转化，但在其内源结构域（即hal形的视盘）中却没有诱导。我们的研究结果表明，选择基因可以根据其获得的组织环境而充当肿瘤驱动程序或抑制剂。

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