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A role for planar cell polarity during early endoderm morphogenesis

机译：内胚层早期形态发生中平面细胞极性的作用

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摘要

The zebrafish endoderm begins to develop at gastrulation stages as a monolayer of cells. The behaviour of the endoderm during gastrulation stages is well understood. However, knowledge of the morphogenic movements of the endoderm during somitogenesis stages, as it forms a mesenchymal rod, is lacking. Here we characterise endodermal development during somitogenesis stages, and describe the morphogenic movements as the endoderm transitions from a monolayer of cells into a mesenchymal endodermal rod. We demonstrate that, unlike the overlying mesoderm, endodermal cells are not polarised during their migration to the midline at early somitogenesis stages. Specifically, we describe the stage at which endodermal cells begin to leave the monolayer, a process we have termed ‘midline aggregation’. The planar cell polarity (PCP) signalling pathway is known to regulate mesodermal and ectodermal cell convergence towards the dorsal midline. However, a role for PCP signalling in endoderm migration to the midline during somitogenesis stages has not been established. In this report, we investigate the role for PCP signalling in multiple phases of endoderm development during somitogenesis stages. Our data exclude involvement of PCP signalling in endodermal cells as they leave the monolayer.
机译：斑马鱼内胚层在胃化阶段开始发展为单层细胞。内胚层在胃形成阶段的行为是众所周知的。然而，缺乏对在形成内胚层期间内胚层形成形态的运动的了解，因为它形成了间充质杆。在这里，我们表征了在胚发生阶段内胚层的发育，并描述了内胚层从单层细胞转变为间充质内胚层棒时的形态发生运动。我们证明，与上层中胚层不同，内胚层细胞在早期的体细胞形成阶段向中线的迁移过程中不会被极化。具体来说，我们描述了内胚层细胞开始离开单层的阶段，这一过程我们称为“中线聚集”。已知平面细胞极性（PCP）信号传导途径可调节中胚层和外胚层细胞向背中线的收敛。但是，尚未确定PCP信号在胚发生阶段内胚层向中线迁移中的作用。在本报告中，我们调查了在体形成过程中内胚层发育多个阶段中PCP信号传导的作用。我们的数据排除了PCP信号在内胚层细胞离开单层时的参与。

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