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首页> 外文期刊>Biology Open >Lipid droplet dynamics during?Schizosaccharomyces pombe?sporulation and their role in spore survival
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Lipid droplet dynamics during?Schizosaccharomyces pombe?sporulation and their role in spore survival

机译：粟酒裂殖酵母孢子形成过程中的脂滴动态及其在孢子存活中的作用

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Upon nitrogen starvation, the fission yeast?Schizosaccharomyces pombe?forms dormant spores; however, the mechanisms by which a spore sustains life without access to exogenous nutrients remain unclear. Lipid droplets are reservoirs of neutral lipids that act as important cellular energy resources. Using live-cell imaging analysis, we found that the lipid droplets of mother cells redistribute to their nascent spores. Notably, this process was actin polymerization-dependent and facilitated by the leading edge proteins of the forespore membrane. Spores lacking triacylglycerol synthesis, which is essential for lipid droplet formation, failed to germinate. Our results suggest that the lipid droplets are important for the sustenance of life in spores.
机译：氮饥饿时，裂殖酵母粟酒裂殖酵母形成休眠的孢子。然而，孢子维持生命而不获取外源营养的机制仍不清楚。脂质小滴是中性脂质的储存库，可作为重要的细胞能源。使用活细胞成像分析，我们发现母细胞的脂质滴重新分布到它们的新生孢子。值得注意的是，该过程是肌动蛋白聚合依赖性的，并由前孢子膜的前缘蛋白促进。缺乏三酰基甘油合成的孢子不能发芽，这对于脂质液滴的形成至关重要。我们的结果表明脂质滴对于维持孢子中的生命很重要。

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