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首页> 外文期刊>Biology Open >The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts
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The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts

机译：Prrx1肢体增强剂标志着损伤反应性皮肤成纤维细胞的成年亚群

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摘要

The heterogeneous properties of dermal cell populations have been posited to contribute toward fibrotic, imperfect wound healing in mammals. Here we characterize an adult population of dermal fibroblasts that maintain an activePrrx1enhancer which originally marked mesenchymal limb progenitors. In contrast to their abundance in limb development, postnatalPrrx1enhancer-positive cells (Prrx1enh+) make up a small subset of adult dermal cells (～0.2%) and reside mainly within dermal perivascular and hair follicle niches. Lineage tracing of adult Prrx1enh+cells shows that they remain in their niches and in small numbers over a long period of time. Upon injury however, Prrx1enh+cells readily migrate into the wound bed and amplify, on average, 16-fold beyond their uninjured numbers. Additionally, following wounding dermal Prrx1enh+cells are found out of their dermal niches and contribute to subcutaneous tissue. Postnatal Prrx1enh+cells are uniquely injury-responsive despite being a meager minority in the adult skin.This article has an associated First Person interview with the first author of the paper.
机译：真皮细胞种群的异质性被认为有助于哺乳动物的纤维化，不完美的伤口愈合。在这里，我们表征了成年成年真皮成纤维细胞群，该成纤维细胞维持了一种活性Prrx1增强子，该增强子最初标志着间充质肢体祖细胞。与四肢发育丰富相比，产后Prrx1增强子阳性细胞（Prrx1enh +）占成年真皮细胞的一小部分（约0.2％），主要位于真皮血管周围和毛囊壁ches中。成年Prrx1enh +细胞的血统追踪表明，它们长时间保持在壁ni中并且数量很少。但是，在受伤时，Prrx1enh +细胞很容易迁移到伤口床中，并且平均扩增超过未受伤数目的16倍。另外，受伤后，真皮Prrx1enh +细胞被发现在它们的真皮壁之外，并有助于皮下组织。出生后的Prrx1enh +细胞尽管在成年皮肤中只占很少的比例，但仍具有独特的损伤反应性。本文对第一人进行了第一人称采访。

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