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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Diagnosis of human immunodeficiency virus type 1 infection in infants by immune complex dissociation p24 assay.
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Diagnosis of human immunodeficiency virus type 1 infection in infants by immune complex dissociation p24 assay.

机译：通过免疫复合物解离p24分析诊断婴儿的人类1型免疫缺陷病毒感染。

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Using immune complex dissociation (ICD), we retrospectively examined serum and plasma of 206 infants aged 0 to 4 months who were perinatally exposed to human immunodeficiency virus (HIV). All samples were analyzed in a blinded manner. Infection status was determined based on the results of HIV culture and Centers for Disease Control and Prevention classification. The overall diagnostic sensitivity of the assay was 59% (93 samples, 73 infants), and specificity was 100% (160 samples, 133 infants). When the samples were analyzed according to age, sensitivity was highest at age 1 to 2 months (17 of 21 infants, 81%). Sensitivities at other ages were 53% at < 1 month, 55% at 2 to 3 months, and 48% at 3 to 4 months (9 of 17, 11 of 20, and 12 of 25 cases, respectively). In 11 evaluable cases there was a possible correlation of p24 antigen quantitation (in picograms per milliliter) with disease progression. We conclude that, as determined in this study, the ICD p24 is a rapid diagnostic assay for HIV infection with a sensitivity of >80% at 1 to 2 months of age and 100% specificity, as evaluated, up to 4 months of age.
机译：使用免疫复合物解离（ICD），我们回顾性检查了206例0至4个月大的围产期暴露于人类免疫缺陷病毒（HIV）的婴儿的血清和血浆。所有样品均以盲法进行分析。根据HIV培养的结果以及疾病控制和预防中心的分类确定感染状态。该方法的总体诊断敏感性为59％（93个样本，73个婴儿），特异性为100％（160个样本，133个婴儿）。根据年龄分析样本时，敏感性在1-2个月时最高（21例婴儿中的17例，占81％）。其他年龄段的敏感度在<1个月时为53％，在2到3个月时为55％，在3-4个月时为48％（分别为17例中的9例，20例中的11例和25例中的12例）。在11例可评估病例中，p24抗原定量（以每毫升皮克计）与疾病进展可能相关。我们得出的结论是，如本研究所述，ICD p24是一种针对HIV感染的快速诊断检测方法，在1至2个月大时的敏感性> 80％，经评估，在4个月大时的特异性为100％。

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