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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Sex-Associated Differences in the Antibody-Dependent Cellular Cytotoxicity Antibody Response to Measles Vaccines
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Sex-Associated Differences in the Antibody-Dependent Cellular Cytotoxicity Antibody Response to Measles Vaccines

机译：麻疹疫苗的抗体依赖性细胞毒性抗体反应的性别相关差异

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In some countries, excessive non-measles-related mortality has been observed among female recipients of high-titer measles vaccines. We determined if differences in the immune response to measles vaccines underlie the excessive female mortality by measuring the measles virus (MV)-specific antibody-dependent cellular cytotoxicity (ADCC) antibody response in 65 3-year-old Gambian children immunized with Edmonston-Zagreb medium-titer (EZ) or Schwarz standard vaccines during infancy. Among the 20 females and 22 males with undetectable anti-MV antibodies at the time of immunization, females had significantly lower ADCC than males (median cytotoxicities of 1/100 serum dilutions = 8.4 and 12%, respectively; P = 0.04). This sex-associated difference was present only among the six female and seven male recipients of EZ vaccine (median cytotoxicities = 5.1 and 19.0%, respectively;P = 0.02). There were no significant sex-associated differences in neutralizing antibody activity. Decreased ADCC antibody activity may contribute to the lower survival rate observed in females receiving high-titer measles vaccination.
机译：在一些国家，在高滴度麻疹疫苗的女性接受者中观察到与非麻疹相关的死亡率过高。我们通过测量65例接受Edmonston-Zagreb免疫的3岁冈比亚儿童中的麻疹病毒（MV）特异性抗体依赖性细胞毒性（ADCC）抗体反应，来确定麻疹疫苗免疫反应的差异是否是女性死亡率过高的原因婴儿期使用中效（EZ）或Schwarz标准疫苗。在免疫时未检测到抗MV抗体的20位女性和22位男性中，女性的ADCC明显低于男性（1/100血清稀释度的中位细胞毒性分别为8.4和12％; P = 0.04）。这种性别相关差异仅在EZ疫苗的六名女性和七名男性接受者中存在（中位细胞毒性分别为5.1和19.0％; P = 0.02）。在中和抗体活性方面没有明显的性别相关差异。 ADCC抗体活性降低可能导致在接受高滴度麻疹疫苗接种的女性中观察到较低的存活率。

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