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Human Dengue Antibodies against Structural and Nonstructural Proteins

机译:针对结构和非结构蛋白的人登革热抗体

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Antibodies against dengue virus type 2 and 4 proteins in acute-phase sera of 10 primary and 10 secondary dengue fever and dengue hemorrhagic fever patients were studied by Western blotting. In the first group the immune response was barely detectable, while in the second group more proteins were detected, with a very strong reaction. Anti-NS1 and -NS3 antibodies were detected mainly in secondary cases. Anti-E, -NS3, and -NS5 antibodies were detected in a high number of cases. The possibility of implementing early diagnostic assays for antigen detection is suggested.
机译:通过蛋白质印迹法研究了10例原发性登革热和10例继发性登革热和登革出血热患者的急性期血清中2型和4型登革病毒蛋白的抗体。在第一组中,几乎无法检测到免疫反应,而在第二组中,检测到更多的蛋白质,并且反应非常强烈。主要在继发病例中检测到抗NS1和-NS3抗体。在很多情况下都检测到了抗E,-NS3和-NS5抗体。建议为抗原检测实施早期诊断测定的可能性。

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