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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Influence of Modified Natural or Synthetic Surfactant Preparations on Growth of Bacteria Causing Infections in the Neonatal Period
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Influence of Modified Natural or Synthetic Surfactant Preparations on Growth of Bacteria Causing Infections in the Neonatal Period

机译：改性天然或合成表面活性剂制剂对新生儿感染细菌生长的影响

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Connatal bacterial pneumonia is common in neonates. Animal studies and initial clinical reports indicate that surfactant dysfunction is involved in the pathophysiology of severe neonatal pneumonia. Since respiratory distress syndrome and connatal pneumonia may be difficult to differentiate in the first hours of life, neonates with respiratory failure due to bacterial infections might receive surfactant. Under such conditions surfactant components might be catabolized by bacteria and promote bacterial growth. We therefore investigated the influence of three modified natural (Curosurf, Alveofact, and Survanta) and two synthetic (Exosurf and Pumactant) surfactant preparations on the growth of bacteria frequently cultured from blood or tracheal aspirate fluid in the first days of life. Group B streptococci (GBS),Staphyloccocus aureus, and Escherichia coliwere incubated in a nutrient-free medium (normal saline) for 5 h at 37°C, together with different surfactants at concentrations of 0, 1, 10, and 20 mg/ml. With the exception of E. coli, incubation in saline alone led to a variable decrease in CFU. In the presence of Alveofact, Exosurf, and Pumactant the decline in bacterial numbers was less marked than in saline alone. Curosurf was bactericidal in a dose-dependent fashion for GBS and had a strong negative impact on the growth of a GBS subtype that lacked the polysaccharide capsule. In contrast, Survanta (10 and 20 mg/ml) significantly promoted the growth of E. coli, indicating that surfactant components may actually serve as nutrients. We conclude that bacterial growth in different surfactant preparations is influenced by microbial species and the composition and dose of the surfactant. Further studies are necessary to elucidate the mechanisms behind our findings and to evaluate the effects of surfactant on bacterial growth in vivo.
机译：新生儿细菌性肺炎很常见。动物研究和初步临床报告表明，表面活性剂功能异常与严重的新生儿肺炎的病理生理有关。由于呼吸窘迫综合征和先天性肺炎在出生后的头几个小时可能难以区分，因此因细菌感染而导致呼吸衰竭的新生儿可能会接受表面活性剂。在这种条件下，表面活性剂成分可能会被细菌分解代谢并促进细菌生长。因此，我们研究了三种改性天然（Curosurf，Alveofact和Survanta）和两种合成（Exosurf和Pumactant）表面活性剂制剂对生命初期频繁从血液或气管吸出液培养的细菌生长的影响。将B组链球菌（GBS），金黄色葡萄球菌和大肠埃希菌在无营养的培养基（生理盐水）中于37°C孵育5小时，表面活性剂的浓度为0、1、10和20 mg / ml。除了 E。大肠杆菌，仅在盐水中孵育会导致CFU明显降低。在存在Alveofact，Exosurf和Pumactant的情况下，细菌数量的下降没有在单独的盐水中明显。 Curosurf对GBS具有杀菌作用，且呈剂量依赖性，对缺乏多糖囊的GBS亚型的生长具有强烈的负面影响。相反，Survanta（10和20 mg / ml）显着促进了 E的生长。大肠杆菌，表明表面活性剂成分实际上可以充当营养物质。我们得出结论，细菌在不同表面活性剂制剂中的生长受到微生物种类以及表面活性剂组成和剂量的影响。为了阐明我们的发现背后的机制并评估表面活性剂对体内细菌生长的影响，有必要进行进一步的研究。

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