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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Immunoglobulin G1 Antibody Response toHelicobacter pylori Heat Shock Protein 60 Is Closely Associated with Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
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Immunoglobulin G1 Antibody Response toHelicobacter pylori Heat Shock Protein 60 Is Closely Associated with Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

机译：幽门螺杆菌热休克蛋白60的免疫球蛋白G1抗体反应与低度胃黏膜相关淋巴组织淋巴瘤密切相关。

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Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is related to Helicobacter pylori infection. Specifically, it has been pointed out that pathogenesis of MALT lymphoma involves the 60-kDa heat shock protein (hsp60). To investigate humoral immune responses to the H. pylori hsp60 in patients with gastroduodenal diseases and patients with MALT lymphoma, the hsp60 ofH. pylori was expressed with a glutathioneS-transferase fusion protein and was purified (recombinant hsp60). Sera were obtained from H. pylori-positive patients with gastroduodenal diseases (MALT lymphoma, n = 13; gastric ulcer, n = 20; duodenal ulcer, n = 20; gastritis,n = 20) and from H. pylori-negative healthy volunteers (n = 9). Sera from patients with MALT lymphoma were also obtained at two times: before and after eradication therapy. Antibodies to hsp60 and H. pylori were assessed by enzyme-linked immunosorbent assay. The levels of immunoglobulin G (IgG) antibodies to the hsp60 of H. pylori-positive patients with gastroduodenal diseases were significantly elevated compared to those in the controls. The levels of IgG1 antibodies to hsp60 were elevated and correlated with the levels of anti-H. pylori antibodies in patients with MALT lymphoma. Humarol immunity against hsp60 may be important and relevant to gastroduodenal diseases induced by H. pylori infection.
机译：胃粘膜相关淋巴样组织淋巴瘤（MALT）与幽门螺杆菌感染有关。特别地，已经指出，MALT淋巴瘤的发病机理涉及60kDa的热休克蛋白（hsp60）。调查对 H的体液免疫反应。胃十二指肠疾病和MALT淋巴瘤患者中的幽门螺杆菌hsp60为 H。用谷胱甘肽 S -转移酶融合蛋白表达幽门螺杆菌并纯化（重组hsp60）。血清获自 H。幽门螺杆菌阳性的胃十二指肠疾病（MALT淋巴瘤， n = 13;胃溃疡， n = 20;十二指肠溃疡， n = 20;胃炎， n = 20），并且来自 H。幽门螺杆菌阴性的健康志愿者（ n = 9）。还两次获得了MALT淋巴瘤患者的血清：根除治疗前后。 hsp60和 H抗体。用酶联免疫吸附法评估幽门螺旋杆菌。针对H的hsp60的免疫球蛋白G（IgG）抗体水平。胃十二指肠疾病的幽门螺杆菌阳性患者与对照组相比明显升高。针对hsp60的IgG1抗体水平升高，并与抗 H水平相关。 MALT淋巴瘤患者的幽门螺杆菌抗体。 Humarol对hsp60的免疫力可能很重要，并且与 H引起的胃十二指肠疾病有关。幽门螺杆菌感染。

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