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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Evaluation of Urine as a Clinical Specimen for Diagnosis of Hepatitis A
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Evaluation of Urine as a Clinical Specimen for Diagnosis of Hepatitis A

机译：尿液作为诊断甲型肝炎的临床标本的评估

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The present study pertains to the evaluation of urine as a specimen for detection of anti-hepatitis A virus (anti-HAV) antibodies. Immunoglobulin M (IgM), IgG, and IgA capture enzyme-linked immunosorbent assays for hepatitis A were performed on paired serum and urine specimens collected from hepatitis A patients (n = 92), healthy individuals (n = 100), non-A hepatitis patients (n = 70), and patients with nonhepatic diseases (n = 64, including 37 renal disease patients). Hepatitis A patients seropositive for anti-HAV IgM showed 95.65% uropositivity. No false-positive reactions were observed in control groups. The uropositivity of anti-HAV IgM persisted during the convalescent phase of the disease. Anti-HAV IgG uropositivity correlated well with corresponding seropositivity in all groups (P > 0.05 for each). No significant difference between the proportions of serum and urine positivity for anti-HAV IgA was noted (P > 0.05 for each). Using seroreactivity as a “gold standard,” the sensitivity and specificity for anti-HAV IgM, anti-HAV IgG, and anti-HAV IgA tests with urine as a specimen were found to be 95.65 and 100%, 97.76 and 76.47%, and 92.23 and 88.18%, respectively. Urine appears to be comparable to serum for diagnosis of recent and past infection with hepatitis A.
机译：本研究涉及评估尿液作为检测抗甲型肝炎病毒（anti-HAV）抗体的标本。甲型肝炎的免疫球蛋白M（IgM），IgG和IgA捕获酶联免疫吸附测定是从甲型肝炎患者（ n = 92），健康个体（ n = 100），非甲型肝炎患者（ n = 70）和非肝病患者（ n = 64），其中包括37位肾脏疾病患者）。抗-HAV IgM呈血清反应阳性的甲型肝炎患者尿阳性率为95.65％。在对照组中未观察到假阳性反应。抗HAV IgM的尿阳性反应在疾病的恢复期持续存在。在所有组中，抗HAV IgG尿阳性率与相应的血清阳性率密切相关（每个 P P

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