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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Elucidation of the Cross-Reactive Immunoglobulin M Response to Human Herpesviruses 6 and 7 on the Basis of Neutralizing Antibodies
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Elucidation of the Cross-Reactive Immunoglobulin M Response to Human Herpesviruses 6 and 7 on the Basis of Neutralizing Antibodies

机译：基于中和抗体对人疱疹病毒6和7的交叉反应性免疫球蛋白M反应的阐明

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Human herpesvirus 6 (HHV-6) is closely related to HHV-7 in terms of genome organization and sequence. The cross-reactive responses between HHV-6 and HHV-7 have been reported by using immunofluorescent techniques. Recently we have shown that neutralizing (NT) antibody responses are specific to each virus and do not cross-react. We took advantage of this and used the NT antibody response to estimate the time of seroconversion to each virus and examined the pattern of humoral immune response, especially the immunoglobulin M (IgM) response, against each virus antigen in the natural course of infection with HHV-6 and HHV-7. In children who experienced HHV-6 infection first, followed by HHV-7 infection, the IgM response at the first HHV-6 infection was directed only against HHV-6, while no IgM response was directed against HHV-7 at the second HHV-7 infection. In contrast, in children who experienced HHV-7 infection first, followed by HHV-6 infection, the IgM response at the first HHV-7 infection was directed not only against HHV-7 but also against HHV-6. These data suggest that cross-reactive responses to heterologous viruses should be taken into consideration when making a diagnosis based on IgM antibody.
机译：人类疱疹病毒6（HHV-6）在基因组组织和序列方面与HHV-7密切相关。已经通过使用免疫荧光技术报道了HHV-6和HHV-7之间的交叉反应性反应。最近，我们显示中和（NT）抗体反应对每种病毒都是特异性的，并且不会交叉反应。我们利用这一优势，并使用NT抗体反应来估计向每种病毒的血清转化时间，并检查了在感染HHV的自然过程中针对每种病毒抗原的体液免疫反应（尤其是免疫球蛋白M（IgM）反应）的模式-6和HHV-7。在首先经历HHV-6感染，然后再经历HHV-7感染的儿童中，第一次HHV-6感染时的IgM反应仅针对HHV-6，而第二次HHV-6中没有针对IHV的IgM反应。 7感染。相反，在首先经历HHV-7感染，然后是HHV-6感染的儿童中，第一次HHV-7感染时的IgM反应不仅针对HHV-7，而且针对HHV-6。这些数据表明，在基于IgM抗体进行诊断时，应考虑对异源病毒的交叉反应。

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