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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Immunological markers of disease progression in patients infected with the human immunodeficiency virus.
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Immunological markers of disease progression in patients infected with the human immunodeficiency virus.

机译：感染人类免疫缺陷病毒的患者疾病进展的免疫学标记。

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Identification of inexpensive and technically simple immunological tests useful in predicting the progression to AIDS in human immunodeficiency virus (HIV)-infected patients would be especially welcome in developing countries, in which 80% of HIV-infected patients reside and health budgets are low. In the current study, we evaluated CD4+ and total lymphocyte counts and the concentrations in serum of beta 2-microglobulin, p24 antigen, and immunoglobulin A (IgA) as predictors of disease progression in 74 Panamanian HIV-positive patients and 50 HIV-negative healthy individuals. Total lymphocyte and CD4(+)-cell counts for AIDS patients (1,451 +/- 811 cells/microliters, P < 0.001, and 238 +/- 392 cells/microliters, P < 0.0001, respectively and asymptomatic patients (2,393 +/- 664 cells/microliters, P > 0.05, and 784 +/- 475 cells/microliters, P < 0.001, respectively) were lower than those observed for healthy subjects (2,596 +/- 631 cells/microliters and 1,120 +/- 296 cells/microliters, respectively). The levels of beta 2-microglobulin and IgA in serum were significantly elevated in patients with AIDS (5.7 +/- 3.6mg/liter, P < 0.001, and 541 +/- 265 mg/dl, P < 0.0002, respectively) and asymptomatic infected subjects (3.4 +/- 2.1 mg/liter, P = 0.001, and 436 +/- 216 mg/dl, P < 0.0001, respectively) compared with the levels in healthy subjects (2.2 +/- 0.7 mg/liter and 204 +/- 113 mg/dl, respectively). Nonstatistically significant differences (P > 0.05) for concentrations of p24 antigen between asymptomatic infected patients (29 +/- 13 pg/ml) and AIDS patients (40 +/- 23 pg/ml) were observed. Total lymphocyte counts of 1,750 cells/microliters or less, CD4 counts of 200 cells/microliters or less, beta 2-microglobulin concentrations in serum of 4 mg/liter or higher, concentrations of IgA in serum of 450 mg/dl or higher, and the presence in serum of p24 antigen were correlated with elevated risks for developing AIDS. Monitoring both total lymphocytes and beta 2-microglobulin identified 91% of the AIDS patients; these assays may allow reductions in the annual number of CD4(+)-cell evaluations and the costs associated with monitoring both total lymphocytes and beta 2-microglobulin identified 91% of the AIDS patients; these assays may allow reductions in the annual number of CD4(+)-cell evaluations and the costs associated with monitoring the immune status of HIV-positive patients.
机译：在发展中国家中，鉴定廉价且技术上简单的免疫学测试可用于预测人类免疫缺陷病毒（HIV）感染者向AIDS的进展将特别受欢迎，因为发展中国家有80％的HIV感染者居住并且健康预算很低。在本研究中，我们评估了74名巴拿马HIV阳性患者和50名HIV阴性健康患者疾病进展的预测指标，包括CD4 +和总淋巴细胞计数以及血清β2-微球蛋白，p24抗原和免疫球蛋白A（IgA）的浓度个人。艾滋病患者和无症状患者的总淋巴细胞和CD4（+）-细胞计数分别为（1,451 +/- 811细胞/微升，P <0.001和238 +/- 392细胞/微升，P <0.0001，无症状患者（2,393 +/- 664细胞/微升（P> 0.05）和784 +/- 475细胞/微升（P <0.001）分别低于健康受试者的观察值（2596 +/- 631细胞/微升和1,120 +/- 296细胞/微升艾滋病患者的血清β2-微球蛋白和IgA水平显着升高（5.7 +/- 3.6mg / dl，P <0.001和541 +/- 265 mg / dl，P <0.0002） ）和无症状感染的受试者（分别为3.4 +/- 2.1 mg / dl，P = 0.001和436 +/- 216 mg / dl，P <0.0001），而健康受试者的水平为（2.2 +/- 0.7毫克/升和204 +/- 113毫克/分升），无症状感染患者（29 +/- 13皮克/毫升）和艾滋病患者之间的p24抗原浓度具有非统计学意义的差异（P> 0.05）（4观察到0 +/- 23 pg / ml。总淋巴细胞计数为1,750个细胞/微升或更少，CD4计数为200细胞/微升或更少，血清中β2-微球蛋白浓度为4 mg / L或更高，血清IgA浓度为450 mg / dl或更高，以及血清中存在p24抗原与患艾滋病的风险增加有关。监测总淋巴细胞和β2-微球蛋白可确定91％的AIDS患者;这些检测可以减少CD4（+）细胞年度评估的数量，并减少91％的AIDS患者与监测总淋巴细胞和β2-微球蛋白有关的费用。这些检测方法可以减少CD4（+）细胞年度评估的数量，并减少与监测HIV阳性患者免疫状况相关的费用。

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