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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Monoclonal yeast killer toxin-like candidacidal anti-idiotypic antibodies.
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Monoclonal yeast killer toxin-like candidacidal anti-idiotypic antibodies.

机译：单克隆酵母杀手毒素样候选酸抗独特型抗体。

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Rat monoclonal yeast killer toxin (KT)-like immunoglobulin M (IgM) anti-idiotypic antibodies (KT-IdAbs) were produced by idiotypic vaccination with a mouse monoclonal antibody (MAb; MAb KT4) that neutralized a Pichia anomala KT characterized by a wide spectrum of antimicrobial activity. The characteristics of the KT-IdAbs were demonstrated by their capacity to compete with the KT to the idiotype of MAb KT4 and to interact with putative KT cell wall receptors (KTRs) of sensitive Candida albicans cells. The internal-image properties of KT-IdAbs were proven by their killer activity against KT-sensitive yeasts. This lethal effect was abolished by prior adsorption of KT-IdAbs with MAb KT4. These findings stressed the potential importance of antibody-mediated immunoprotection against candidiasis and suggested a feasible experimental approach for producing antimicrobial receptor antibodies without purifying the receptor. KT-IdAbs might represent the basis for producing engineered derivatives with a high potential for effective therapeutic antifungal activity.
机译：大鼠单克隆酵母杀伤毒素（KT）样免疫球蛋白M（IgM）抗独特型抗体（KT-IdAbs）是通过用小鼠单克隆抗体（MAb; MAb KT4）进行独特型疫苗接种而产生的，该小鼠单克隆抗体（MAb; MAb KT4）中和了特征在于广泛的Pichia anomala KT抗菌活性谱。 KT-IdAbs的特征通过与KT竞争成为单克隆抗体KT4的独特型并与敏感的白色念珠菌细胞的假定KT细胞壁受体（KTR）相互作用的能力得到证明。 KT-IdAb对KT敏感酵母的杀伤活性证明了其内部图像特性。通过事先用MAb KT4吸附KT-IdAb，消除了这种致命作用。这些发现强调了针对念珠菌病的抗体介导的免疫保护的潜在重要性，并提出了在不纯化受体的情况下产生抗微生物受体抗体的可行实验方法。 KT-IdAbs可能代表生产具有高潜力的有效治疗性抗真菌活性的工程化衍生物的基础。

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