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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Elevated Levels of Lipopolysaccharide-Binding Protein and Soluble CD14 in Plasma in Neonatal Early-Onset Sepsis
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Elevated Levels of Lipopolysaccharide-Binding Protein and Soluble CD14 in Plasma in Neonatal Early-Onset Sepsis

机译：新生儿早发型脓毒症血浆中脂多糖结合蛋白和可溶性CD14的水平升高

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No data on lipopolysaccharide-binding protein (LBP) in newborns with sepsis have been available up to now. We therefore determined levels of LBP and soluble CD14 (sCD14) in plasma of healthy and septic neonates in order to evaluate their potential diagnostic role. The study included prospectively collected patient samples of two recently published studies on cytokine expression in neonatal sepsis. Twenty-nine septic patients were enrolled in the present analysis. Samples—either cord blood or peripheral blood—from patients admitted within the first 24 h of life for suspicion of sepsis and cord blood samples of a control group of 40 healthy mature infants delivered spontaneously were analyzed. For seven patients of the septic group, a second sample collected between 24 and 48 h of life was available. Levels of sCD14 and LBP in plasma were determined by an enzyme immunoassay using recombinant CD14 and LBP as standards. LBP and sCD14 were correlated to cytokine plasma levels. In septic neonates, LBP (median, 36.6 versus 7.8 μg/ml; P < 0.001) and sCD14 (median, 0.42 versus 0.28 μg/ml; P < 0.001) levels were highly elevated when compared to those of healthy neonates and strongly correlated to granulocyte colony-stimulating factor (G-CSF), interleukin-1β (IL-1β), IL-6, and IL-8 levels. LBP levels in septic neonates analyzed between 24 and 48 h of life even increased when compared to samples obtained at or shortly after delivery (median, 36.6 versus 60 μg/ml; P = 0.038). In summary, levels of LBP in plasma of neonates with early-onset sepsis are significantly elevated; the elevated plasma levels seem to persist for more than 24 h, which could provide the clinician with a prolonged time period to identify the newborn with bacterial sepsis.
机译：迄今为止，尚无败血症新生儿脂多糖结合蛋白（LBP）的数据。因此，我们确定了健康和脓毒症新生儿血浆中的LBP和可溶性CD14（sCD14）水平，以评估其潜在的诊断作用。该研究包括前瞻性收集的两项最近发表的关于新生儿败血症中细胞因子表达的研究的患者样本。本分析纳入了29名败血症患者。分析了在生命的最初24小时内因怀疑败血症而入院的患者的脐带血或外周血样本，并分析了自发分娩的40名健康成熟婴儿的对照组的脐带血样本。对于脓毒症组的7名患者，可以使用生命24至48小时之间收集的第二份样本。用重组CD14和LBP作为标准，通过酶免疫测定法测定血浆中sCD14和LBP的水平。 LBP和sCD14与细胞因子血浆水平相关。在败血性新生儿中，LBP（中位数为36.6 vs 7.8μg/ ml; P <0.001）和sCD14（中位数为0.42 vs 0.28μg/ ml; P <0.001）水平与健康新生儿相比，血红蛋白水平显着升高，并且与粒细胞集落刺激因子（G-CSF），白介素1β（IL-1β），IL-6和IL-8水平高度相关。与分娩时或分娩后不久获得的样本相比，脓毒症新生儿在生命24至48小时内的LBP水平甚至更高（中位数36.6对60μg/ ml; P = 0.038）。总之，患有早发性败血症的新生儿血浆中的LBP水平显着升高。升高的血浆水平似乎持续超过24小时，这可以为临床医生提供更长的时间来鉴定患有细菌性败血症的新生儿。

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