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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Predictors of survival in human immunodeficiency virus type 1-seropositive intravenous drug users.
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Predictors of survival in human immunodeficiency virus type 1-seropositive intravenous drug users.

机译：人类免疫缺陷病毒1型血清阳性静脉吸毒者的生存预测指标。

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In an ongoing prospective study of street-recruited intravenous drug users (IDUs) in Miami, Fla., 116 human immunodeficiency virus type 1 (HIV-1)-infected IDUs were monitored for up to 7 years. This provided an opportunity to evaluate baseline immunological parameters as potential predictors of survival among HIV-1-infected IDUs. As expected, HIV-1-infected IDUs who had an advanced stage of the disease (Centers for Disease Control and Prevention classification III or IV); p24 antigenemia; human T-cell leukemia virus type 1/2 seropositivity; low CD4 counts (< or = 200); low hemoglobin (< or = 14), high serum immunoglobulin A (IgA) (> 500 mg/dl), or high serum IgG (> or = 3,500 mg/dl) levels; or low proliferative responses to pokeweed mitogen (< or = 1,500 cpm) and to phytohemagglutinin (< or = 80,000 cpm) at baseline had worse survival rates. Results from multivariate Cox's models of survival showed that the baseline serum IgG level, serum IgA level, and CD4 count independently predict survival in HIV-1-infected IDUs. Cross-validation procedures verified the above-mentioned findings. These findings support the routine consideration of serum immunoglobulin levels in addition to CD4 count, especially in early evaluation of disease stage, as these evaluations may modify application of prophylaxis and treatment for HIV-1-infected IDUs. We recommend consideration of use of serum IgG and IgA as immunological markers for long-range prediction of survival in HIV-1-infected IDUs. These determinations are less onerous and more appropriate for use in field studies and financially less favored settings.
机译：在佛罗里达州迈阿密进行的一项街头招募静脉吸毒者（IDU）的一项正在进行的前瞻性研究中，对长达116年的116种人类免疫缺陷病毒1型（HIV-1）感染的IDU进行了监测。这为评估基线免疫学参数提供了机会，这些基线免疫学参数可作为感染HIV-1的IDU中存活率的潜在预测指标。正如预期的那样，患有艾滋病晚期的HIV-1感染的注射吸毒者（疾病控制和预防中心分类为III或IV）; p24抗原血症;人类T细胞白血病病毒1/2血清反应阳性; CD4计数低（<或= 200）;低血红蛋白（<或= 14），高血清免疫球蛋白A（IgA）（> 500 mg / dl）或高血清IgG（>或= 3,500 mg / dl）;在基线时对商陆有丝分裂原（<或= 1,500 cpm）和植物血凝素（<或= 80,000 cpm）的低或低增殖反应具有较差的存活率。多元Cox生存模型的结果表明，基线血清IgG水平，血清IgA水平和CD4计数独立地预测感染HIV-1的IDU中的生存。交叉验证程序验证了上述发现。这些发现支持常规的血清CD4计数之外的血清免疫球蛋白水平的考虑，尤其是在疾病早期评估中，因为这些评估可能会改变HIV-1感染的IDU的预防和治疗应用。我们建议考虑使用血清IgG和IgA作为免疫学标记物，以长期预测HIV-1感染的IDU的存活率。这些测定结果较不繁琐，更适合用于实地研究，并且在经济上不太有利。

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