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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Sensitivity and specificity of the borreliacidal-antibody test during early Lyme disease: a 'gold standard'?
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Sensitivity and specificity of the borreliacidal-antibody test during early Lyme disease: a 'gold standard'?

机译：早期莱姆病期间硼酸酸抗体检测的敏感性和特异性：“金标准”？

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The serodiagnosis of early Lyme disease has been plagued with problems of sensitivity and specificity. We found that the flow-cytometric borreliacidal-antibody test had a sensitivity of 72% for the detection of patients with early Lyme disease. By contrast, the sensitivity of the enzyme immunofluorescence assay was 28%. The enhanced sensitivity of the borreliacidal-antibody test was due to the use of Borrelia burgdorferi 50772, which lacks OspA and OspB. When B. burgdorferi 297, which expresses both OspA and OspB, was used, the sensitivity of the borreliacidal-antibody test was 15%. Our results also showed that the borreliacidal-antibody test was specific. No borreliacidal activity was detected in normal sera or in sera from patients with mononucleosis, rheumatoid factor, or syphilis. These results demonstrate that the flow-cytometric borreliacidal-antibody test may be the laboratory "gold standard" for the serodiagnosis of Lyme disease.
机译：早期莱姆病的血清诊断一直存在敏感性和特异性问题。我们发现，流式细胞仪硼酸酸性抗体检测对于早期莱姆病患者的检测灵敏度为72％。相比之下，酶免疫荧光测定的灵敏度为28％。硼瑞酸抗体测试灵敏度的提高是由于使用了缺少OspA和OspB的伯氏疏螺旋体50772。当使用同时表达OspA和OspB的B. burgdorferi 297时，硼酸酸抗体测试的灵敏度为15％。我们的结果还表明，硼酸酸抗体测试具有特异性。在正常血清或单核细胞增多症，类风湿因子或梅毒患者的血清中未检测到硼瑞酸活性。这些结果表明，流式细胞仪硼酸酸性抗体检测可能是莱姆病血清学诊断的实验室“金标准”。

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