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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome.
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Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome.

机译：败血症或全身性炎症反应综合征患者的循环补体蛋白。

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The systemic inflammatory response of the body to invading microorganisms, termed sepsis, leads to profound activation of the complement system. Pathophysiological concepts suggest that complement activation occurs very early in this syndrome. Thus, we discuss whether the determination of concentrations of the complement components C3a, C5a, and C3 in plasma as well as of the C3a/C3 ratio might be helpful to diagnose sepsis early. For this purpose, 33 patients from an intensive care unit were monitored for 10 days. In comparison with healthy donors, C3a levels and the C3a/C3 ratio of intensive-care-unit patients were significantly elevated (P < 0.0001) on admission. In contrast, C3 levels were significantly reduced (P < 0.0001) but increased during the study. C5a levels in the plasma of healthy donors and patients were identical. Twenty-two of 33 patients fulfilled microbiological and clinical criteria of sepsis. Eleven patients had signs of systemic inflammatory response syndrome but no microbiological evidence of sepsis. The groups could be differentiated from each other by their C3a levels or their C3a/C3 ratios during the first 24 h after the clinical onset of sepsis (P < 0.05). Septic patients in shock had higher C3a levels than normotensive septic patients, although the differences were not significant. Nonsurvivors had significantly higher C3a levels on admission than survivors (P = 0.0185). No differences were found between septic patients who developed adult respiratory distress syndrome and those who did not. Thus, determination of C3a concentrations in plasma may prove useful (i) to diagnose sepsis early, (ii) to differentiate between patients with sepsis and those with systemic inflammatory response syndrome, and (iii) to assess prognosis.
机译：机体对入侵微生物的全身性炎症反应（称为败血症）可导致补体系统的深度活化。病理生理学概念表明补体激活发生在该综合征的早期。因此，我们讨论确定血浆中补体成分C3a，C5a和C3的浓度以及C3a / C3的比例是否有助于早期诊断败血症。为此，对来自重症监护室的33名患者进行了10天的监测。与健康捐赠者相比，重症监护病房患者的C3a水平和C3a / C3比值在入院时显着升高（P <0.0001）。相反，在研究期间，C3水平显着降低（P <0.0001），但升高。健康供体和患者血浆中的C5a水平相同。 33名患者中有22名符合败血症的微生物学和临床标准。 11例患者有全身性炎症反应综合征的体征，但无败血症的微生物学证据。在败血症临床发作后的最初24小时内，各组之间的C3a水平或C3a / C3比值之间可以进行区分（P <0.05）。休克的败血症患者的C3a水平高于血压正常的败血症患者，尽管差异不显着。非幸存者入院时的C3a水平明显高于幸存者（P = 0.0185）。在发展成成人呼吸窘迫综合征的脓毒症患者与未患脓毒症的患者之间没有发现差异。因此，血浆中C3a浓度的测定可证明（i）早期诊断败血症，（ii）区分脓毒症患者和系统性炎症反应综合征患者，以及（iii）评估预后。

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