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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Increased Interleukin-6 Levels in Nasal Lavage Samples following Experimental Influenza A Virus Infection
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Increased Interleukin-6 Levels in Nasal Lavage Samples following Experimental Influenza A Virus Infection

机译：实验性甲型流感病毒感染后鼻灌洗样本中白介素6水平升高

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Interleukin-6 (IL-6) is a pleotropic cytokine implicated in the pathogenesis of local inflammation during viral upper respiratory infections. This study determined if experimental influenza A virus infection causes local IL-6 production. Seventeen healthy, adult subjects were intranasally inoculated, by course drops, with a safety-tested strain of influenza A/Kawasaki/86 (H1N1) virus. Nasal lavage samples were collected, symptoms were recorded, and expelled nasal secretions were weighed once before and then daily for 8 days after the virus inoculation. Lavage samples were submitted for virus culture and were examined for IL-6 and IL-4 by enzyme-linked immunosorbent assay. The IL-6, but not IL-4, levels were significantly increased in the nasal lavage samples of the 12 subjects who shed virus but not in those of the 5 subjects who did not shed virus. Moreover, the elevations in IL-6 levels were related temporally to the development of nasal symptoms and secretions but not to systemic symptoms. These results suggest a role for locally produced IL-6 in the pathogenesis and expressed symptomatology of influenza A virus infection.
机译：白介素6（IL-6）是一种多效性细胞因子，与病毒性上呼吸道感染过程中局部炎症的发病机制有关。这项研究确定了实验性甲型流感病毒感染是否引起局部IL-6产生。通过滴鼻剂，对十七名健康的成人受试者进行鼻内接种A型流感/川崎/ 86（H1N1）病毒的安全性测试。收集鼻灌洗液样品，记录症状，并在称重病毒后称重一次鼻分泌物，然后称重一次，然后每天连续8天。将灌洗样品送去进行病毒培养，并通过酶联免疫吸附测定法检查IL-6和IL-4。在排出病毒的12位受试者的鼻灌洗液样本中，IL-6的水平显着升高，但在未排出病毒的5位受试者的鼻灌洗液中却没有升高。此外，IL-6水平的升高在时间上与鼻症状和分泌物的发展有关，但与全身症状无关。这些结果表明，局部产生的IL-6在甲型流感病毒感染的发病机理和表达的症状方面具有作用。

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