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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Antibody Response of Patients withHelicobacter pylori-Related Gastric Adenocarcinoma: Significance of Anti-CagA Antibodies
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Antibody Response of Patients withHelicobacter pylori-Related Gastric Adenocarcinoma: Significance of Anti-CagA Antibodies

机译：幽门螺杆菌相关性胃腺癌患者的抗体应答：抗CagA抗体的意义。

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摘要

The aim of this study was to search for a specific antibody pattern in sera from patients suffering from Helicobacter pylori-related gastric adenocarcinoma (GAC). The serological response of 22 patients suffering from GAC, 31 patients with gastroduodenal ulcer, and 39 asymptomatic subjects was analyzed using immunoblotting performed with three H. pylori strains: strain ATCC 43579; strain B110, isolated from a patient with ulcers; and strain B225, isolated from a patient with GAC. In addition, the latex agglutination test Pyloriset Dry was used to analyze ambiguous sera. H. pylori seropositivity was 75% in the GAC group, 61.3% in the ulcer group, and 56.4% in the asymptomatic group. Anti-CagA antibodies were found more often in the GAC group (48.8%) and in the ulcer group (47.3%) than in the asymptomatic group (21.2%). These percentages depended on the strain used as an antigen: in the GAC group, the anti-CagA frequencies were 93.3, 40, and 13.3% with strains B225, B110, and ATCC 43579, respectively. Thus the presence of anti-CagA antibodies was increased in patients suffering from H. pylori-related GAC, in particular when the CagA antigen was from a GAC strain. These data suggest the existence of a CagA protein specifically expressed by H. pylori strains isolated from GAC patients.
机译：这项研究的目的是寻找患有幽门螺杆菌相关胃腺癌（GAC）的患者血清中的特异性抗体模式。使用3种H免疫印迹分析22例GAC患者，31例十二指肠溃疡患者和39例无症状受试者的血清学反应。幽门螺杆菌菌株：ATCC 43579菌株;从溃疡患者中分离出的菌株B110;分离自GAC患者的B225菌株。另外，使用乳胶凝集试验Pyloriset Dry来分析歧义血清。 H。 GAC组的幽门螺杆菌血清阳性率为75％，溃疡组为61.3％，无症状组为56.4％。与无症状组（21.2％）相比，GAC组（48.8％）和溃疡组（47.3％）中发现抗CagA抗体的频率更高。这些百分比取决于用作抗原的菌株：在GAC组中，菌株B225，B110和ATCC 43579的抗CagA频率分别为93.3％，40％和13.3％。因此，患有 H的患者中抗CagA抗体的存在增加。幽门螺杆菌相关的GAC，尤其是当CagA抗原来自GAC株时。这些数据表明存在由 H特异性表达的CagA蛋白。从GAC患者中分离出幽门螺杆菌菌株。

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