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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Detection of Phenolic Glycolipid I ofMycobacterium leprae in Sera from Leprosy Patients before and after Start of Multidrug Therapy
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Detection of Phenolic Glycolipid I ofMycobacterium leprae in Sera from Leprosy Patients before and after Start of Multidrug Therapy

机译：开始多药治疗前后麻风病人血清中分枝杆菌麻风酚糖脂I的检测

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A total of 100 untreated new leprosy patients were recruited prospectively and examined for the presence of phenolic glycolipid I (PGL-I) antigen in their serum specimens by dot enzyme-linked immunosorbent assay (ELISA) using rabbit anti-PGL-I antiserum. The presence of circulating PGL-I antigen was closely related to the bacterial indices (BI) of the patients. The PGL-I antigen was detectable in 27 (93.1%) of 29 patients with a BI of 4.0 or above and in 15 (68.2%) of 22 patients with a BI of 3.0 to 3.9. However, none of the 37 patients with a BI of less than 1.9 had detectable PGL-I antigen by the methods used in this study. The level of PGL-I in serum declined rapidly by about 90% 1 month after the start of multidrug therapy. This study showed clearly that anti-PGL-I IgM antibodies and circulating PGL-I antigen levels reflect the bacterial loads in untreated leprosy patients. The serological parameters based on the PGL-I antigen may therefore be useful in the assessment of leprosy patients at the time of diagnosis and possibly in monitoring patients following chemotherapy.
机译：前瞻性招募了总共100名未经治疗的新麻风病人，并使用兔抗PGL-1抗血清通过斑点酶联免疫吸附测定（ELISA）检查了他们的血清标本中酚糖脂I（PGL-1）抗原的存在。循环中的PGL-1抗原的存在与患者的细菌指数（BI）密切相关。在29例BI≥4.0的患者中有27例（93.1％）可以检测到PGL-1抗原，在22例BI≥3.0至3.9的患者中有15例（68.2％）可以检测到。然而，通过本研究中使用的方法，BI小于1.9的37例患者中没有一个可检测到PGL-1抗原。在开始多药治疗后1个月，血清中PGL-1的水平迅速下降了约90％。这项研究清楚地表明，抗PGL-1 IgM抗体和循环中的PGL-1抗原水平反映了未经治疗的麻风病人的细菌负荷。因此，基于PGL-1抗原的血清学参数在诊断时可用于评估麻风病人，并可能用于监测化疗后的病人。

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