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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Antenatal Screening for Hepatitis B and Antibodies to Toxoplasma gondii and Rubella Virus: Evaluation of Two Commercial Immunoassay Systems
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Antenatal Screening for Hepatitis B and Antibodies to Toxoplasma gondii and Rubella Virus: Evaluation of Two Commercial Immunoassay Systems

机译：乙型肝炎和弓形虫和风疹病毒抗体的产前筛查：两种商业免疫测定系统的评估

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A comparative evaluation of the Abbott AxSYM and DPC Immulite random-access analyzers was performed using 497 prospectively collected serum samples. These samples were sent to the laboratory for routine antenatal screening for hepatitis B surface antigen and immunoglobulin G (IgG) and IgM antibodies to Toxoplasma gondii and rubella virus. The overall agreement between the two assay systems ranged from 97.4 to 100%. After discrepancy analysis, the outcome in terms of sensitivity and specificity varied from 98.2 to 100% for all but one of the assays tested. The AxSYM rubella virus IgG assay tended to report protective or indeterminate antibody levels in 1% of the samples. This shortcoming might be overcome by raising the cutoff of the microparticle enzyme immunoassay system.
机译：使用497个预期收集的血清样本对Abbott AxSYM和DPC Immulite随机访问分析仪进行了比较评估。这些样本被送往实验室，以进行常规的产前筛查，以检测乙型肝炎表面抗原和免疫球蛋白G（IgG）以及针对弓形虫和风疹病毒的IgM抗体。两种测定系统之间的总体一致性为97.4％至100％。经过差异分析后，除一种测试外，所有灵敏度和特异性的结果在98.2％到100％之间变化。 AxSYM风疹病毒IgG分析倾向于报告1％样品中的保护性或不确定抗体水平。该缺点可以通过提高微粒酶免疫测定系统的临界值来克服。

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