Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines, Chemokines, and T-Cell Proliferation

Teresa Krakauer

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Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines, Chemokines, and T-Cell Proliferation

机译：半胱天冬酶抑制剂可减轻超抗原诱导的炎性细胞因子，趋化因子和T细胞增殖。

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Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). A pan-caspase inhibitor suppressed SE-stimulated T-cell proliferation and the production of cytokines and chemokines by human peripheral blood mononuclear cells. These data suggest that caspase inhibitors may represent a novel therapeutic modality for treating SE-induced toxic shock.

机译：促炎细胞因子介导超抗原葡萄球菌外毒素（SE）的毒性作用。泛半胱氨酸蛋白酶抑制剂可抑制SE刺激的T细胞增殖以及人外周血单核细胞产生的细胞因子和趋化因子。这些数据表明半胱天冬酶抑制剂可能代表了一种新的治疗方式，用于治疗SE诱导的毒性休克。

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《Clinical and diagnostic laboratory immunology》 |2004年第3期|共4页
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Teresa Krakauer;
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1. Tigecycline attenuates staphylococcal superantigen-induced T-cell proliferation and production of cytokines and chemokines. [J] . Saliba R, Paasch L, El Solh A Immunopharmacology and immunotoxicology . 2009,第4期

机译：Tigecycline减弱葡萄球菌超抗原诱导的T细胞增殖以及细胞因子和趋化因子的产生。
2. Coordinate suppression of superantigen-induced cytokine production and T-cell proliferation by a small nonpeptidic inhibitor of class II major histocompatibility complex and CD4 interaction. [J] . Krakauer T Antimicrobial agents and chemotherapy. . 2000,第4期

机译：通过II类主要组织相容性复合物和CD4相互作用的小型非肽类抑制剂来协调抑制超抗原诱导的细胞因子产生和T细胞增殖。
3. Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines. [J] . Krakauer T, Chen X, Howard OM, Immunopharmacology and immunotoxicology . 2005,第1期

机译：雷公藤内酯醇可减弱内毒素和葡萄球菌外毒素诱导的T细胞增殖以及细胞因子和趋化因子的产生。
4. A Novel Murine Model of Biomaterial Induced Osteolysis: Expression of the Chemokine MCP-1 and the Pro-Inflammatory Cytokines IL-1β and IL-6 [C] . Warme B., Epstein N.J., Trindade M.C.D., Annual meeting of the Society For Biomaterials . 2003

机译：一种新型的生物材料诱导骨溶解的小鼠模型：趋化因子MCP-1和促炎性细胞因子IL-1β和IL-6的表达
5. The Attenuating Effects of 1,2,3,4,6-Penta-O-Galloyl-β-D Glucose (PGG) on the Inflammatory Cytokines Release in TNF-α-activated Triple Negative Breast Cancer (TNBC) Cells [D] . Alghamdi, Sumiah. 2019

机译：1,2,3,4,6-五核苷酸-β-D葡萄糖（PGG）对TNF-α-活化的三阴性乳腺癌（TNBC）细胞炎症细胞因子释放的衰减效应
6. Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines Chemokines and T-Cell Proliferation [O] . Teresa Krakauer 2004

机译：半胱天冬酶抑制剂可减轻超抗原诱导的炎性细胞因子趋化因子和T细胞增殖。
7. Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines, Chemokines, and T-Cell Proliferation [O] . Krakauer, Teresa 2004

机译：半胱天冬酶抑制剂减弱超抗原诱导的炎性细胞因子，趋化因子和T细胞增殖。
8. Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines, Chemokines, and T-Cell Proliferation. [R] . Krakauer, T. 2004

机译：半胱天冬酶抑制剂减弱超抗原诱导的炎性细胞因子，趋化因子和T细胞增殖。

Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines, Chemokines, and T-Cell Proliferation

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