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首页> 外文期刊>Clinical and diagnostic laboratory immunology >High Prevalence of Seropositivity to a Major Allergen of Anisakis simplex, Ani s 1, in Dyspeptic Patients
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High Prevalence of Seropositivity to a Major Allergen of Anisakis simplex, Ani s 1, in Dyspeptic Patients

机译：在消化不良患者中对正反抗茴香的主要过敏原的血清阳性反应发生率很高

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Finding evidence of anisakidosis requires invasive methods. We have developed a serological assay based on the detection of an immunoglobulin E (IgE) specifically directed against Ani s 1 protein, a major parasite allergen of Anisakis simplex, which has shown a high level of accuracy in the diagnosis of anisakidosis. We used this tool to determine the prevalence of anti-Ani s 1 IgE in dyspeptic patients and to investigate if its seropositivity could be related to epidemiological factors other than raw fish consumption. A total of 174 dyspeptic patients who submitted to upper digestive tract endoscopy were studied. Specific IgE against Ani s 1 was determined by immunoblotting. Quantitative information on smoking, alcohol consumption, and fish consumption as well as a history of gastric surgery was recorded. Twenty-four (13.8%) patients were seropositive for Ani s 1 protein. The seroprevalence of anti-Ani s 1 IgE increased with age in patients who were less than 62 years old (P = 0.047). Seropositivity to Ani s 1 was associated with the consumption of fish in vinegar (P < 0.001), raw fish (P = 0.001), and smoked fish (P = 0.007). There was no relationship between anti-Ani s 1 IgE seropositivity and the number of cigarettes smoked (P = 0.098) or alcohol intake (P = 0.179). Five patients had undergone previous gastric surgery, and three of those patients were seropositive for Ani s 1 (P = 0.019). In multivariate analysis, the consumption of fish in vinegar (P = 0.006), raw fish (P = 0.017), and smoked fish (P = 0.002) and a history of gastric surgery (P = 0.005) were independent factors associated with anti-Ani s 1 IgE detection. In conclusion, at present, anisakidosis might frequently be underdiagnosed, and it might have a clinical role in patients with upper dyspeptic symptoms. Uncooked-fish ingestion and previous gastric surgery were associated with seropositivity for Ani s 1 protein.
机译：寻找茴香歧病的证据需要采用侵入性方法。我们已经基于检测针对Ani s 1蛋白的免疫球蛋白E（IgE）进行了血清学检测，Ani s 1蛋白是的主要寄生虫变应原，已经显示出很高的准确性。诊断为茴香皮病。我们使用该工具来确定消化不良患者中抗Ani s 1 IgE的患病率，并调查其血清阳性是否与生鱼食用以外的流行病学因素有关。共有174名消化不良的患者接受了上消化道内镜检查。通过免疫印迹确定针对Ani s 1的特异性IgE。记录有关吸烟，饮酒和食用鱼的定量信息以及胃手术史。 24名（13.8％）患者的Ani s 1蛋白呈血清阳性。年龄小于62岁的患者中抗Ani s 1 IgE的血清阳性率随年龄增加而增加（ P = 0.047）。对Ani s 1的血清阳性与食醋（ P <0.001），生鱼（ P = 0.001）和熏制鱼（ P = 0.007）。抗Ani s 1 IgE血清阳性与吸烟量（ P = 0.098）或饮酒量（ P = 0.179）之间没有关系。五名患者曾经接受过胃外科手术，其中三名患者的Ani s 1呈血清阳性（ P = 0.019）。在多变量分析中，食醋（ P = 0.006），生鱼（ P = 0.017）和熏制鱼（ P = 0.002）和胃手术史（ P = 0.005）是与抗Ani s 1 IgE检测相关的独立因素。综上所述，目前，茴香皮病可能经常被误诊，对上消化不良症状的患者可能具有临床作用。未煮熟的鱼的摄入和先前的胃手术与Ani s 1蛋白的血清阳性有关。

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