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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Serotype Specificity of the Neutralizing-Antibody Response Induced by the Individual Surface Proteins of Rotavirus in Natural Infections of Young Children
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Serotype Specificity of the Neutralizing-Antibody Response Induced by the Individual Surface Proteins of Rotavirus in Natural Infections of Young Children

机译：轮状病毒个体表面蛋白在幼儿自然感染中诱导的中和抗体应答的血清型特异性

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The relative contribution of the rotavirus surface proteins, VP4 and VP7, to the induction of homotypic as well as heterotypic neutralizing antibodies (NtAbs) in natural infections was studied. The NtAb titers of paired sera from 70 infants with serologically defined primary rotavirus infections were determined with a panel of rotavirus reassortants having one surface protein from a human rotavirus (serotypes G1 to G4 for VP7 and P1A and P1B for VP4) and the other surface protein from a heterologous animal rotavirus strain. A subset of 37 children were evaluated for epitope-specific antibodies to the two proteins by an epitope-blocking assay. The infants were found to seroconvert more frequently to VP4 than to VP7 by both methods, although the titers of the seroconverters were higher to VP7 than to VP4. Both proteins induced homotypic as well as heterotypic NtAbs. G1 VP7 frequently induced a response to both G1 and G3 VP7s, while G3 VP7 and P1A VP4 induced mostly homotypic responses.
机译：研究了轮状病毒表面蛋白VP4和VP7对自然感染中同型和异型中和抗体（NtAbs）诱导的相对贡献。用一组轮状病毒重配剂测定70例具有血清学定义的原发性轮状病毒感染的婴儿的配对血清的NtAb滴度，该重组体具有一种来自人轮状病毒的表面蛋白（VP7和P1A的血清型为G1至G4，VP4的血清型为P1B）来自异源动物轮状病毒株。通过表位阻断试验评估了37名儿童的一部分，针对这两种蛋白的表位特异性抗体。两种方法均发现婴儿血清转化为VP4的频率高于VP7，尽管血清转化者的效价比VP4高。两种蛋白均诱导同型和异型NtAb。 G1 VP7经常诱导对G1和G3 VP7的响应，而G3 VP7和P1A VP4则主要诱导同型响应。

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