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Age-Related Changes in Blood Lymphocyte Subsets of Saudi Arabian Healthy Children

机译：沙特阿拉伯健康儿童的血液淋巴细胞亚群的年龄相关变化

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The age-related changes in absolute and percentage values of lymphocyte subsets in the peripheral blood of healthy children of different ages (1 month to 13 years) were studied by flow cytometry. The absolute and percentage values for most lymphocyte subpopulations differed substantially with age. Comparisons among age groups from infants through adults revealed progressive declines in the absolute numbers of leukocytes, total lymphocytes, and T, B, and natural killer (NK) cells. The percentages of T cells increased with age. Within the T-lymphocyte population, the CD8+ subset increased but the CD4+ subset decreased, resulting in a declining CD4+/CD8+ ratio. The percentage of B cells declined, but that of NK cells remained unchanged. The percentage of HLA-DR+ T cells increased over time, but their number changed inconsistently. Our findings confirm and extend earlier reports on age-related changes in lymphocyte subpopulations. These data should be useful in the interpretation of disease-related changes, as well as therapy-dependent alterations, in lymphocyte subsets in children of different age groups.
机译：通过流式细胞术研究了不同年龄（1个月至13岁）健康儿童外周血淋巴细胞亚群的绝对值和百分比值的年龄相关变化。大多数淋巴细胞亚群的绝对值和百分比值随着年龄的增长而显着不同。从婴儿到成人的年龄组之间的比较表明，白细胞，总淋巴细胞，T，B和自然杀伤（NK）细胞的绝对数量逐渐减少。 T细胞的百分比随年龄增长而增加。在T淋巴细胞群体中，CD8 + 子集增加，但CD4 + 子集减少，导致CD4 + / CD8 + 比率。 B细胞的百分比下降，但是NK细胞的百分比保持不变。 HLA-DR + T细胞的百分比随时间增加，但数量却不一致。我们的发现证实并扩展了关于淋巴细胞亚群与年龄相关的变化的早期报道。这些数据应有助于解释不同年龄组儿童的淋巴细胞亚群中与疾病有关的变化以及与治疗有关的改变。

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