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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Antibody to Human Endogenous Retrovirus Peptide in Urine of Human Immunodeficiency Virus Type 1-Positive Patients
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Antibody to Human Endogenous Retrovirus Peptide in Urine of Human Immunodeficiency Virus Type 1-Positive Patients

机译：人类免疫缺陷病毒1型阳性患者尿液中的人类内源性逆转录病毒肽抗体

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Human endogenous retrovirus (HERV)-like sequences are normal inherited elements that constitute several hundredths of the human genome. The expression of genes located within these elements can occur as a consequence of several different events, including persistent inflammation or genotoxic events. Antibodies to endogenous retroviral gene products have been found in a number of infectious, chronic, and malignant diseases, suggesting a role in disease initiation and progression. We studied human immunodeficiency virus type 1 (HIV-1)-infected patients for evidence of urine antibody to a HERV peptide and investigated correlates with clinical and laboratory parameters. Forty-three HIV-1-infected patients in documented asymptomatic, symptomatic, or AIDS stages of disease and 21 age- and gender-matched, uninfected controls were tested for antibody to HERV-related peptide 4.1. Urine specimens were examined in a blinded fashion with the Calypte Biomedical Corp. experimental enzyme immunoassay for antibody to peptide 4.1. Results were compared with demographic data, medical history, clinical state of disease, and results of other laboratory tests. Thirty-six percent of the asymptomatic (Centers for Disease Control and Prevention [CDC] category A) and 81.3% of both the symptomatic (CDC category B) and AIDS (CDC category C) patients were positive for antibody to HERV-related peptide 4.1. None of the controls were positive. In this study, antibodies to HERV-related peptide 4.1 were found more frequently in patients with advanced stages (categories B and C) of HIV-1 disease than in those patients with an earlier stage (category A) of HIV disease. In HIV patients, severe immunosuppression, defined as having had at least one opportunistic infection, correlated with the expression of antibody to a HERV-related peptide.
机译：人类内源性逆转录病毒（HERV）样序列是正常的遗传元件，构成人类基因组的百分之几百。位于这些元件内的基因的表达可能是几种不同事件（包括持续性炎症或遗传毒性事件）的结果。已在许多传染性，慢性和恶性疾病中发现了针对内源性逆转录病毒基因产物的抗体，表明在疾病的发生和发展中发挥了作用。我们研究了人类免疫缺陷病毒1型（HIV-1）感染的患者，以获得针对HERV肽的尿液抗体的证据，并研究了其与临床和实验室参数的相关性。对有文献记录的无症状，有症状或AIDS阶段的43名HIV-1感染患者以及21个年龄和性别匹配的未感染对照进行了HERV相关肽4.1抗体测试。用Calypte Biomedical Corp.实验性酶免疫法以盲法检查尿液标本中抗4.1肽的抗体。将结果与人口统计数据，病史，疾病的临床状况以及其他实验室检查的结果进行比较。无症状（疾病控制和预防中心[CDC] A类）的百分之三十六和有症状（CDC B类）和艾滋病（CDC C类）的无症状患者中，针对HERV相关肽4.1的抗体呈阳性。对照均无阳性。在这项研究中，与HIV疾病的早期阶段（A类）相比，HIV-1疾病的晚期阶段（B和C类）患者发现HERV相关肽4.1抗体的频率更高。在HIV患者中，严重的免疫抑制（定义为患有至少一种机会性感染）与针对HERV相关肽的抗体的表达相关。

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