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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Transplacental Transmission of Serotype-Specific Pneumococcal Antibodies in a Brazilian Population
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Transplacental Transmission of Serotype-Specific Pneumococcal Antibodies in a Brazilian Population

机译：在巴西人群中经胎盘传播血清型特异性肺炎球菌抗体。

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The highest incidence of severe pneumococcal infections in children occurs in the first 6 months of life; however, immunization of infants with the existing polysaccharide vaccines is ineffective. We wished to determine the prevalence of immunoglobulin G (IgG) pneumococcal antibodies in unimmunized Brazilian mothers and their transplacental transmission to term and preterm infants. Total IgG, IgG1 and -2 subclass levels, and IgG antibodies against Streptococcus pneumoniae serotypes 1, 3, 6B, 9V, and 14 were determined in 15 pairs of mothers and term newborns (gestational age, ≥37 weeks) and in 18 pairs of mothers and preterm newborns (gestational age, 32 to 36 weeks). Serotype-specific anti-pneumococcal antibodies were detected by a recently standardized enzyme-linked immunosorbent assay calibrated with the 89-SF reference serum. Varying percentages of the mothers had antibody concentrations below arbitrarily defined protective levels: 33% for serotype 1, 67% for serotype 3, 30% for serotype 6B, 52% for serotype 9V, and 22% for serotype 14. In term newborns, IgG1 concentrations were slightly higher than maternal concentrations; in preterm newborns, the concentrations were much lower. Concentrations of IgG2 in term and preterm infants were significantly lower than in the mothers. Transplacental transmission of antibodies to serotypes 3 and 14 was clearly different from that of antibodies to serotypes 1, 6B, and 9V. Concentrations of IgG antibodies against serotypes 3 and 14 were similar to or higher than those of the mothers; against serotypes 1, 6B, and 9V they ranged from 77 to 83% of maternal concentrations in term newborns and also in preterm infants, although transplacental transmission of antibodies was proportionally lower for each specific serotype in preterm than in term infants. These data are relevant for developing strategies to protect infants against pneumococcal infections in the first months of life. Our findings and a review of existing information stress the importance of understanding the relationships among pneumococcal immunization, IgG subclass antibodies to individual serotypes, transplacental transport, half-life, and antibody function and their protective values against infection.
机译：儿童严重肺炎球菌感染的最高发生发生在生命的头六个月。但是，用现有的多糖疫苗对婴儿进行免疫是无效的。我们希望确定免疫球蛋白G（IgG）肺炎球菌抗体在未免疫的巴西母亲中的患病率及其通过胎盘传播给足月和早产儿的情况。在15对母亲和足月新生儿（胎龄≥37岁）中确定了总的IgG，IgG1和-2亚类水平以及抗肺炎链球菌血清型1、3、6B，9V和14的IgG抗体周和18对母亲和早产儿（胎龄为32至36周）。通过最近标准化的，用89-SF参考血清校准的酶联免疫吸附测定法检测到血清型特异性抗肺炎球菌抗体。有不同百分比的母亲的抗体浓度低于任意定义的保护水平：血清型1为33％，血清型3为67％，血清型6B为30％，血清型9V为52％，血清型14为22％。在足月新生儿中，IgG1浓度略高于母亲浓度;在早产儿，其浓度要低得多。足月和早产儿的IgG2浓度明显低于母亲。血清型3和14抗体的胎盘传播明显不同于血清型1、6B和9V的抗体。抗血清型3和14的IgG抗体浓度与母亲的浓度相似或更高。相对于血清型1、6B和9V，足月新生儿和早产儿的血清浓度为母体浓度的77％至83％，尽管早产儿每种特定血清型的胎盘抗体传播比例均比足月儿低。这些数据与制定策略来保护婴儿在生命的头几个月免受肺炎球菌感染有关。我们的发现和对现有信息的回顾强调了理解肺炎球菌免疫，针对个别血清型的IgG亚类抗体，胎盘运输，半衰期和抗体功能及其对感染的保护价值之间关系的重要性。

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