Diagnosis of Tuberculosis Based on the Two Specific Antigens ESAT-6 and CFP10

Laurens A. H. van Pinxteren; Pernille Ravn; Else Marie Agger; John Pollock; Peter Andersen

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Diagnosis of Tuberculosis Based on the Two Specific Antigens ESAT-6 and CFP10

机译：基于两种特异性抗原ESAT-6和CFP10的结核病诊断

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Tests based on tuberculin purified protein derivative (PPD) cannot distinguish between tuberculosis infection, Mycobacterium bovis BCG vaccination, or exposure to environmental mycobacteria. The present study investigated the diagnostic potential of twoMycobacterium tuberculosis-specific antigens (ESAT-6 and CFP10) in experimental animals as well as during natural infection in humans and cattle. Both antigens were frequently recognized in vivo and in vitro based on the induction of delayed-type hypersensitivity responses and the ability to induce gamma interferon production by lymphocytes, respectively. The combination of ESAT-6 and CFP10 was found to be highly sensitive and specific for both in vivo and in vitro diagnosis. In humans, the combination had a high sensitivity (73%) and a much higher specificity (93%) than PPD (7%).

机译：基于结核菌素纯化蛋白衍生物（PPD）的测试无法区分结核病感染，牛分枝杆菌BCG疫苗接种或环境分枝杆菌暴露。本研究调查了两种结核分枝杆菌特异性抗原（ESAT-6和CFP10）在实验动物以及人和牛的自然感染过程中的诊断潜力。分别基于诱导迟发型超敏反应和诱导淋巴细胞产生γ-干扰素的能力，两种抗原在体内和体外都经常被识别。发现ESAT-6和CFP10的组合对于体内和体外诊断都是高度敏感和特异性的。在人类中，该组合比PPD（7％）具有更高的敏感性（73％）和更高的特异性（93％）。

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《Clinical and diagnostic laboratory immunology》 |2000年第2期|共6页
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Laurens A. H. van Pinxteren; Pernille Ravn; Else Marie Agger; John Pollock; Peter Andersen;
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中图分类诊断学;
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1. Detection of bovine tuberculosis in herds with different disease prevalence and influence of paratuberculosis infection on PPDB and ESAT-6/CFP10 specificity. [J] . Aagaard C., Govaerts M., Meikle V., Preventive Veterinary Medicine . 2010,第3a4期

机译：检测不同疾病流行程度的牛结核病以及副结核病感染对PPDB和ESAT-6 / CFP10特异性的影响。
2. Performance of whole blood IFN-gamma test for tuberculosis diagnosis based on PPD or the specific antigens ESAT-6 and CFP-10. [J] . Brock I, Munk ME, Kok-Jensen A, The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease . 2001,第5期

机译：基于PPD或特定抗原ESAT-6和CFP-10的全血IFN-γ测试对结核病的诊断。
3. Mycobacterium Tuberculosis Infection in Rhesus Monkeys (Macaca mulatta) and Evaluation of ESAT-6 and CFP10 as Immunodiagnostic Antigens [J] . Fangui Min, Yu Zhang, Jinchun Pan, Experimental Animals . 2013,第4期

机译：恒河猴（Macaca mulatta）的结核分枝杆菌感染和ESAT-6和CFP10作为免疫诊断抗原的评估
4. Pulmonary delivery of microencapsulated ESAT-6 from Mycobacterium Tuberculosis is superior toparenteral delivery methods for inducing specific cell-mediated immune responses [C] . Z. K. Carpenter, J. E. Eyles, E. D. Williamson Controlled Release Society annual meeting . 2004

机译：结核分枝杆菌的微囊化ESAT-6的肺部递送优于胃肠外递送方法，可诱导特定的细胞介导的免疫反应
5. Characterization of gammadelta T cells relevant for protective tuberculosis immunity: T cell specificity, antigen identification and mechanisms of inhibition. [D] . Spencer, Charles T. 2008

机译：与保护性结核免疫相关的γδT细胞的表征：T细胞特异性，抗原鉴定和抑制机制。
6. Diagnosis of Tuberculosis Based on the Two Specific Antigens ESAT-6 and CFP10 [O] . Laurens A. H. van Pinxteren, Pernille Ravn, Else Marie Agger, 2000

机译：基于两种特异性抗原ESAT-6和CFP10的结核病诊断
7. Diagnosis of Tuberculosis Based on the Two Specific Antigens ESAT-6 and CFP10 [O] . van Pinxteren, Laurens A. H., Ravn, Pernille, Agger, Else Marie, 2000

机译：基于两种特异性抗原ESAT-6和CFP10的结核病诊断

Diagnosis of Tuberculosis Based on the Two Specific Antigens ESAT-6 and CFP10

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