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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Kinetics of Antibody Responses in Rickettsia africae and Rickettsia conorii Infections
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Kinetics of Antibody Responses in Rickettsia africae and Rickettsia conorii Infections

机译：非洲立克次体和康氏立克次体感染的抗体反应动力学。

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摘要

African tick-bite fever, caused by Rickettsia africae, is the most common tick-borne rickettsiosis in sub-Saharan Africa. Mediterranean spotted fever due to Rickettsia conorii also occurs in the region but is more prevalent in Mediterranean countries. Using microimmunofluorescence, we compared the development of immunoglobulin G (IgG) and IgM titers in 48 patients with African tick-bite fever and 48 patients with Mediterranean spotted fever. Doxycycline treatment within 7 days from the onset of disease significantly prevented the development of antibodies to R. africae. In patients with African tick-bite fever, the median times to seroconversion with IgG and IgM were 28 and 25 days, respectively, after the onset of symptoms. These were significantly longer by a median of 6 days for IgG and 9 days for IgM than the times for seroconversion in patients with Mediterranean spotted fever (P < 10?2). We recommend that sera collected 4 weeks after the onset of signs of patients with suspected African tick-bite fever should be used for the definitive serological diagnosis of R. africae infections.
机译：非洲立克次氏菌引起的非洲tick咬热是撒哈拉以南非洲最常见的tick传播立克次体病。该地区也发生由 Rickettsia conorii 引起的地中海斑点热，但在地中海国家更为普遍。使用微免疫荧光技术，我们比较了48例非洲tick咬热和48例地中海斑热患者的免疫球蛋白G（IgG）和IgM滴度的发展。疾病发作后7天之内的强力霉素治疗显着阻止了 R抗体的产生。非洲。在非洲tick咬热患者中，症状发作后，IgG和IgM进行​​血清转换的中位时间分别为28天和25天。与地中海斑疹热（ P <10 ？2 ）患者的血清转化时间相比，IgG的中位数显着延长了6天，IgM的中位数是9天。我们建议在怀疑患有非洲tick叮咬热的患者出现症状后4周收集的血清应用于 R的明确血清学诊断。非洲感染。

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