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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Immunoglobulin G Subclass Profile of Antimeasles Response in Vaccinated Children and in Adults with Measles History
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Immunoglobulin G Subclass Profile of Antimeasles Response in Vaccinated Children and in Adults with Measles History

机译：接种过疫苗的儿童和有麻疹病史的成人的time虫反应的免疫球蛋白G亚类概况

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The aim of this study was to investigate measles-specific immunoglobulin G (IgG) subclass profile in vaccinated children and in adults with natural infection. Serum samples were collected before and 30 days after vaccination. The sera from 51 late convalescent adults and seven adults with natural measles infection at the 12th day after onset of rash have been also investigated. Measles IgG antibodies and specific IgG subclasses were tested by enzyme-linked immunosorbent techniques. In children younger than 3 years, the predominant subclass was IgG3, which contributed, on average, 63.3% of the total IgG response. The contributions of specific IgG1 and IgG4 to the total IgG antimeasles response were lower (19.9% and 16.8%, respectively), whereas IgG2 was not found. In contrast, in the group of children older than 4 years, just IgG2 was a predominant subclass; it contributed 42.6% of the total IgG response. Other subclasses were also present but the contribution was much lower. In adult volunteers with measles history, IgG2 was a predominant subclass of total IgG. Thus, in early convalescence IgG2 contributed 62% of the total IgG response, whereas in late convalescence the contribution was lower (41.4%). There were no visible differences in IgG subclass composition between subjects with natural infection and vaccinated children except those below 3 years of age. The humoral immune response of such subjects is immature and the IgG2 subclass of virus-specific antibodies has not been revealed in the sera.
机译：这项研究的目的是调查接种疫苗的儿童和患有自然感染的成人中的麻疹特异性免疫球蛋白G（IgG）亚类概况。在接种疫苗之前和之后30天收集血清样品。还研究了51名晚期恢复期成年人和7名在出疹后第12天有自然麻疹感染的成年人的血清。通过酶联免疫吸附技术测试了麻疹IgG抗体和特定IgG亚类。在3岁以下的儿童中，主要的亚类是IgG3，平均占总IgG应答的63.3％。特异性IgG1和IgG4对总IgG耐风疹反应的贡献较低（分别为19.9％和16.8％），而未发现IgG2。相反，在4岁以上的儿童组中，仅IgG2是主要的亚类。它贡献了总IgG反应的42.6％。其他子类也存在，但贡献要低得多。在有麻疹病史的成年志愿者中，IgG2是总IgG的主要亚类。因此，在恢复期初期，IgG2贡献了总IgG反应的62％，而在恢复期后期，贡献较低（41.4％）。患有自然感染的受试者与接种疫苗的儿童（3岁以下者）之间的IgG亚类组成没有明显差异。此类受试者的体液免疫反应尚不成熟，并且病毒特异性抗体的IgG2亚类尚未在血清中发现。

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