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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Evaluation of Three Immunoassays Used for Detection of Anti-Rubella Virus Immunoglobulin M Antibodies
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Evaluation of Three Immunoassays Used for Detection of Anti-Rubella Virus Immunoglobulin M Antibodies

机译：三种用于检测抗风疹病毒免疫球蛋白M抗体的免疫测定方法的评估

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摘要

Three automated assays (Abbott AxSYM, Bayer ADVIA Centaur, and bioMerieux VIDAS) used for the detection of rubella virus-specific immunoglobulin M were evaluated. A total of 57 samples from individuals with evidence of infection with rubella virus were used to estimate sensitivity, and 220 samples from blood donors and individuals attending an antenatal clinic who had no evidence of recent infection were used to estimate specificity. Seroconversion panels comprising an additional 31 samples from four individuals were used to determine clinical sensitivity. Samples containing potentially cross-reacting substances were also tested. The sensitivities of the three assays ranged from 84.2 to 96.5%, and the specificities ranged from 96.8 to 99.9%. The Abbott AxSYM assay detected more reactive samples than the other two assays when a panel of 57 positive samples was tested. Bayer ADVIA Centaur detected more reactive samples in the seroconversion panels than the other two assays. All three assays evaluated reported a reactive result in 1 or more of the 48 samples containing potentially cross-reacting analytes. The assays demonstrated comparable performance in testing of a well-characterized panel of samples.
机译：评估了三种用于检测风疹病毒特异性免疫球蛋白M的自动化检测方法（Abbott AxSYM，Bayer ADVIA Centaur和bioMerieux VIDAS）。共有57份有风疹病毒感染迹象的样本用于评估敏感性，而有220份来自献血者和产前诊所就诊者（无近期感染证据）的样本用于评估特异性。使用包括来自四个个体的另外的31个样品的血清转化板来确定临床敏感性。还测试了含有潜在交叉反应物质的样品。三种测定的灵敏度范围为84.2至96.5％，特异性范围为96.8至99.9％。当测试一组57个阳性样品时，雅培AxSYM分析比其他两个分析检测到的反应性样品更多。与其他两种测定法相比，拜耳ADVIA Centaur在血清转化图中检测到的反应性样品更多。评估的所有三种测定均报告了48种样品中可能含有交叉反应分析物的一种或多种的反应结果。该测定法在测试特征明确的一组样品中表现出可比的性能。

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