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首页> 外文期刊>Clinical and Experimental Dental Research >Discontinuation of simvastatin leads to a rebound phenomenon and results in immediate peri-implant bone loss
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Discontinuation of simvastatin leads to a rebound phenomenon and results in immediate peri-implant bone loss

机译：辛伐他汀停药会导致反弹现象，并导致即刻种植体周围骨质流失

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摘要

Abstract Although administration of simvastatin has been reported to promote bone formation, the effect of short-term simvastatin administration is not well known. Following implant installation, 10-week-old male Wistar rats ( n = 24) were divided into two groups randomly. The experimental group received 10 mg/kg of simvastatin daily for seven days. Then simvastatin administration was discontinued, and the animals were observed up to 28 days. Animals in the control group underwent the same procedure but received saline instead of simvastatin. All animals were analyzed by micro-computed tomography. Samples at days 14 and 21 were subjected to histological analyses. After seven days of simvastatin administration, more new bone formation around the implant was observed in the simvastatin group compared with the control group. Seven days after simvastatin discontinuation, however, the amount of peri-implant trabecular bone began to decrease. Results from morphometric analysis also showed a reduction in new bone area after day 7, which was lowest at day 14. These results were confirmed by histological analyses. In contrast, both the peri-implant trabecular bone and new bone area were maintained in the control group. Short-term administration of simvastatin may affect implant stability owing to a rebound phenomenon and an immediate loss of peri-implant bone.
机译：摘要尽管据报道使用辛伐他汀可促进骨形成，但短期服用辛伐他汀的效果尚不明确。安装植入物后，将10周龄的雄性Wistar大鼠（n = 24）随机分为两组。实验组每天接受10 mg / kg辛伐他汀治疗，持续7天。然后停止辛伐他汀给药，并观察动物长达28天。对照组中的动物进行相同的程序，但是接受生理盐水代替辛伐他汀。通过微计算机断层摄影术分析所有动物。在第14天和第21天对样品进行组织学分析。辛伐他汀给药7天后，与对照组相比，辛伐他汀组观察到更多的新骨形成。辛伐他汀停用后7天，植入物周围小梁骨的数量开始减少。形态分析结果还显示，第7天后新骨面积减少，在第14天最低。这些结果通过组织学分析得到了证实。相比之下，对照组的种植体周围小梁骨和新骨面积均得以维持。短期服用辛伐他汀可能会由于反弹现象和种植体周围骨的立即丢失而影响种植体的稳定性。

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