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首页> 外文期刊>Communicative & Integrative Biology >Identification of the zebrafish red nucleus using Wheat Germ Agglutinin transneuronal tracing
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Identification of the zebrafish red nucleus using Wheat Germ Agglutinin transneuronal tracing

机译：小麦胚芽凝集素跨神经元示踪法鉴定斑马鱼红色核

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The red nucleus is located in the rostral midbrain of the vertebrate brain and controls motor coordination during locomotion. It receives input from the cerebellum and sends its output to the spinal cord. The presence of the red nucleus is well established in tetrapods, and its existence has also been suggested in teleosts but its presence and position has still been under discussion. By using wheat germ agglutinin (WGA) as a genetically encoded anterograde tracer, we recently identified contralateral projections from the cerebellum to a putative red nucleus in the zebrafish midbrain tegmentum. In this report we further revealed red nucleus derived from this contralateral afferent from the cerebellum using WGA and contralateral projections to the hindbrain-spinal cord junction site using DiI-mediated retrograde tracing. Thus the structure that we have identified by anterograde and retrograde tracing fulfills the anatomical demands for the red nucleus: the location in the midbrain tegmentum, contralateral afferent from the cerebellum (cerebello-ruber projection) and contralateral efferent to the spinal cord (rubro-spinal projection).
机译：红色核位于脊椎动物大脑的大脑中脑，在运动过程中控制运动协调。它从小脑接收输入，并将其输出发送到脊髓。红色核的存在已在四足动物中得到了很好的确立，并且硬骨鱼中也暗示了其存在，但其存在和位置仍在讨论中。通过使用小麦胚芽凝集素（WGA）作为遗传编码的顺行示踪剂，我们最近在斑马鱼中脑被盖中发现了小脑到推定的红色核的对侧投射。在本报告中，我们进一步揭示了使用WGA从小脑传入对侧的红色核，以及使用DiI介导的逆行追踪对侧投影到后脑-脊髓连接位点。因此，我们通过顺行和逆行追踪确定的结构满足了对红色核的解剖学要求：在中脑被盖处，小脑的对侧传入（小脑-鲁伯投影）和脊髓的对侧传出（Rubro-spinal）投影）。

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