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Nuclear actin and transcriptional activation

机译：核肌动蛋白和转录激活

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Differentiated cells do not revert to an embryonic state in normal development. However, the method called nuclear reprogramming enables these differentiated cells to be reversed to an embryonic state. One essential event in the reprogramming process is reactivation of embryonic genes such as Oct4 (also known as Pou5f1 ). This reprogramming of transcriptional programs can be achieved by transplantation of mammalian somatic nuclei to the giant Xenopus laevis oocyte nucleus, referred to as the germinal vesicle (GV). Factors and mechanisms responsible for this transcriptional reprogramming have not been elucidated. Recently, we have found that a polymerized form of actin is abundantly present in nuclei transplanted into the Xenopus oocyte nucleus and plays an important role in transcriptional reactivation of Oct4 . This study emphasizes a significant contribution of nuclear actin in transcriptional activation. Here, we discuss possible roles of nuclear actin in Xenopus oocytes and in other cell types in the context of transcriptional activation.
机译：分化的细胞在正常发育中不会回复到胚胎状态。但是，称为核重编程的方法可使这些分化的细胞逆转至胚胎状态。重编程过程中的一个基本事件是胚胎基因（例如 Oct4（也称为 Pou5f1））的重新激活。可以通过将哺乳动物体细胞核移植到称为生小囊泡（GV）的巨型非洲爪蟾卵母细胞核中来实现转录程序的这种重新编程。尚未阐明负责这种转录重编程的因素和机制。最近，我们发现肌动蛋白的聚合形式大量存在于移植到非洲爪蟾卵母细胞核中的核中，并在 Oct4的转录激活中起重要作用。这项研究强调核肌动蛋白在转录激活中的重大贡献。在这里，我们讨论了在转录激活的背景下，核肌动蛋白在非洲爪蟾卵母细胞和其他细胞类型中的可能作用。

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