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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Correlation between serological and mucosal inflammatory responses to Helicobacter pylori.
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Correlation between serological and mucosal inflammatory responses to Helicobacter pylori.

机译：幽门螺杆菌的血清学和粘膜炎症反应之间的相关性。

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In 82 patients who underwent gastroduodenoscopy, acute and chronic gastric mucosal inflammation was scored for severity, and systemic humoral immune responses to Helicobacter pylori antigens were assessed by enzyme-linked immunosorbent assays. On the basis of culture, gastric histology, and serologic evaluation, 33 patients were classified as H. pylori infected and 36 were classified as uninfected. Thirteen patients had negative cultures and stains but were seropositive and were analyzed separately from the other two groups. Specific serum immunoglobulin G (IgG) subclass responses to H. pylori whole-cell antigens and specific IgG responses to the 54-kDa heat shock protein homolog (Hp54K) and vacuolating cytotoxin were significantly greater in infected than in uninfected patients as were specific IgA responses to whole-cell antigens and cytotoxin (P < 0.001). Among the H. pylori-infected persons, serum IgG responses to Hp54K and to the vacuolating cytotoxin were correlated with acute mucosal inflammatory scores. In contrast, serum IgA responses to whole-cell sonicate and to vacuolating cytotoxin were inversely related to chronic inflammatory scores. By multivariant regression analysis, only specific serum IgG responses to Hp54K correlated with severity of inflammation (both acute and chronic; P < 0.001); these responses may be markers of inflammation or these antibodies could play a direct role in the pathogenesis of H. pylori-induced inflammation.
机译：在接受胃十二指肠镜检查的82例患者中，对急性和慢性胃粘膜炎症的严重程度进行了评分，并通过酶联免疫吸附试验评估了对幽门螺杆菌抗原的全身性体液免疫反应。根据培养，胃组织学和血清学评估，将33例患者归为幽门螺杆菌感染，将36例归为未感染。 13名患者的培养物和染色阴性，但血清反应阳性，并与其他两组分别进行了分析。对幽门螺杆菌全细胞抗原的特异性血清免疫球蛋白G（IgG）亚类应答，对54 kDa热休克蛋白同源物（Hp54K）和空泡细胞毒素的特异性IgG应答与未感染的患者相比明显高于未感染的患者全细胞抗原和细胞毒素（P <0.001）。在幽门螺杆菌感染者中，血清对Hp54K和空泡细胞毒素的IgG反应与急性粘膜炎性评分相关。相反，血清IgA对全细胞超声和空泡细胞毒素的反应与慢性炎症评分呈负相关。通过多变量回归分析，只有针对Hp54K的特异性血清IgG反应与炎症的严重程度相关（急性和慢性; P <0.001）;并且这些反应可能是炎症的标志，或者这些抗体可能在幽门螺杆菌诱导的炎症的发病机理中起直接作用。

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