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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Serologic Testing for Celiac Disease in the United States: Results of a Multilaboratory Comparison Study
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Serologic Testing for Celiac Disease in the United States: Results of a Multilaboratory Comparison Study

机译：在美国进行腹腔疾病的血清学检测：多实验室比较研究的结果

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摘要

The aim of this study was to compare the efficiencies of six reference laboratories for serologic testing for celiac disease. Serum from 20 patients with untreated celiac disease and from 20 controls was thawed, divided, and distributed to each participating laboratory, which performed endomysial antibody tests. Five laboratories also performed antigliadin antibody tests. Sensitivity for endomysial antibody immunoglobulin A (IgA) varied from 57 to 90%. In all laboratories, the specificity for celiac disease was 100%. The sensitivity and specificity for both IgA and IgG antigliadin antibody varied significantly. When results from all three tests were combined in each laboratory, sensitivity was 90 to 100%. The specificity for endomysial antibody was 100% in the laboratories. Sensitivity was less than reported previously. Standardization of these tests is needed in the United States.
机译：这项研究的目的是比较六个参考实验室进行乳糜泻血清学检测的效率。将来自20例未经治疗的腹腔疾病患者和20例对照的血清解冻，分开，并分配给每个参与实验室，这些实验室进行了肌内膜抗体测试。五个实验室还进行了抗麦胶蛋白抗体测试。肌内膜抗体免疫球蛋白A（IgA）的敏感性从57％到90％不等。在所有实验室中，乳糜泻的特异性均为100％。 IgA和IgG抗麦醇溶蛋白抗体的敏感性和特异性差异很大。当在每个实验室中将所有三个测试的结果合并时，灵敏度为90％至100％。在实验室中，肌内膜抗体的特异性为100％。灵敏度低于以前的报告。这些测试在美国需要标准化。

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