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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Humoral Immune Response in Chromoblastomycosis during and after Therapy
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Humoral Immune Response in Chromoblastomycosis during and after Therapy

机译：色母细胞治疗期间和之后的体液免疫反应

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A longitudinal study was carried out in Madagascar, the most important focus of chromoblastomycosis (P. Esterre, A. Andriantsimahavandy, E. Ramarcel, and J. L. Pecarrere, Am. J. Trop. Med. Hyg. 55:45–47, 1996), to investigate natural immunity to this disease. Sequential blood samples were obtained before, during, and at the end of a successful therapeutic trial with terbinafine, a new antifungal drug. Using enzyme-linked immunosorbent assay and immunoblot methods, detailed analyses of antibody concentration and antigen mapping were conducted for 136 serum samples and tentatively correlated to epidemiological and pathobiological data. Two different cytoplasmic antigens, corresponding to the two fungal species involved (Fonsecaea pedrosoi and Cladophialophora carrionii), were used to analyze the distribution of different classes of immunoglobulins. This was done with respect to the origin of the isolates, clinical and pathobiological. Although strong individual variations were noticed, some major antigens (one of 18.5 kDa specific for F. pedrosoi and two of 23.5 and 33 kDa, respectively, specific for C. carrionii) corresponded to high antibody prevalence and concentration. As some antigenic components were also detected by immunoglobulin M (IgM) and IgA antibodies, the role that these specific antibodies could play in the immune response is discussed.
机译：在马达加斯加进行了纵向研究，马达加斯加是成色菌病最重要的焦点（P. Esterre，A。Andriantsimahavandy，E。Ramarcel和JL Pecarrere，Am。J. Trop。Med。Hyg。55：45-47，1996） ，以调查对这种疾病的自然免疫力。在新的抗真菌药物特比萘芬成功的治疗试验之前，之中和结束时，均获得了连续的血样。使用酶联免疫吸附测定和免疫印迹方法，对136个血清样品进行了抗体浓度和抗原作图的详细分析，并初步与流行病学和病理生物学数据相关。分别使用了两种不同的细胞质抗原，分别对应于两种涉及的真菌（Fonsecaea pedrosoi 和 Cladophialophora carrionii ），以分析不同类别的免疫球蛋白的分布。相对于分离物的来源，临床和病理生物学来进行。尽管注意到了很强的个体变异性，但还是存在一些主要抗原（特异于小白僵菌的特异性抗原分别为18.5 kDa和特异于毛白僵菌的特异性抗原分别为23.5和33 kDa）。对应于高抗体患病率和浓度。由于免疫球蛋白M（IgM）和IgA抗体还检测到一些抗原成分，因此讨论了这些特异性抗体在免疫反应中可能发挥的作用。

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