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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Altered Expression of TAP-1 and Major Histocompatibility Complex Class I in Laryngeal Papillomatosis: Correlation of TAP-1 with Disease
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Altered Expression of TAP-1 and Major Histocompatibility Complex Class I in Laryngeal Papillomatosis: Correlation of TAP-1 with Disease

机译：TAP-1和主要组织相容性复合体I类在喉乳头状瘤病中的表达改变：TAP-1与疾病的相关性

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Recurrent respiratory papillomatosis (RRP) is an insidious disease caused by human papillomavirus (HPV) infection. It is characterized by a variable clinical course that can include frequent disease recurrence, significant morbidity, and occasional mortality. The mechanisms responsible for the variability in the clinical course and the persistence of latent HPV infection remain unknown. Effective T-cell-mediated clearance of HPV-infected cells may be defective in patients with RRP, leading to recurrent disease and failure to suppress latent HPV reactivation. This study describes the down-regulation of the transporter associated with antigen presentation (TAP-1) and the major histocompatibility complex (MHC) class I protein expression in laryngeal papilloma tissue biopsies and cell culture of primary explants. There was a statistically significant correlation between reduction of TAP-1 expression in biopsy tissues and rapid recurrence of disease. Patients with RRP had less frequent recurrence if their papillomas expressed TAP-1 at levels close to that of normal tissue, compared with those with very low expression of TAP-1, who had frequent recurrence (32 versus 5 weeks to the next surgical intervention). These findings suggest that HPV may evade immune recognition by down-regulating class I MHC cell surface expression via decreased TAP-1 levels. Expression of TAP-1 could be used for prognostic evaluation of disease severity. Gamma interferon was able to restore class I MHC expression at the surfaces of laryngeal papilloma cells in culture. This up-regulation of class I MHC antigen at the cell surface potentially allows the infected cell to become a target for the immune system again. This finding provides some promise for nonsurgical treatment of laryngeal papillomas.
机译：复发性呼吸道乳头状瘤病（RRP）是由人乳头瘤病毒（HPV）感染引起的隐性疾病。它的特点是临床过程可变，包括频繁的疾病复发，明显的发病率和偶发的死亡率。尚不清楚导致临床过程变异和潜在HPV感染持续存在的机制。 RRP患者中有效的T细胞介导的HPV感染细胞清除可能是缺陷的，从而导致疾病复发和无法抑制潜在的HPV激活。这项研究描述了与抗原呈递（TAP-1）和主要组织相容性复合体（MHC）I类蛋白在喉乳头状瘤组织活检和原代外植体细胞培养中相关的转运蛋白的下调。活检组织中TAP-1表达的减少与疾病的快速复发之间存在统计学上的显着相关性。如果RP-1的乳头状瘤的TAP-1的表达水平与正常组织相近，那么RRP的患者的复发率就较低，而TAP-1的表达却很低，复发率较高（32例与下一次外科手术相比5周） 。这些发现表明，HPV可能通过降低TAP-1水平下调I类MHC细胞表面表达而逃避免疫识别。 TAP-1的表达可用于疾病严重程度的预后评估。 γ干扰素能够在培养的喉乳头状瘤细胞表面恢复I类MHC表达。细胞表面I类MHC抗原的这种上调可能使受感染的细胞再次成为免疫系统的靶标。这一发现为喉头乳头状瘤的非手术治疗提供了希望。

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